Pressure natriuresis in salt-sensitive and salt-resistant Sabra rats

Hypertension
V GrossF C Luft

Abstract

Salt-resistant (SBN/y) and salt-sensitive (SBH/y) Sabra rats are a useful model of salt-sensitive hypertension with incompletely explored renal mechanisms. We investigated their pressure-natriuresis curves, with and without deoxycorticosterone acetate (DOCA)-salt treatment. To differentiate between extrinsic neural and hormonal mechanisms and intrinsic renal influences, we performed experiments with neural denervation, adrenalectomy, and infusions of vasopressin, norepinephrine, 17-hydroxycorticosterone, and aldosterone as well as without these maneuvers. In untreated SBN/y without controlled neural and circulating hormonal factors, urine flow and sodium excretion increased from 32 to 95 microL/min per gram kidney weight (gkwt) and from 4 to 17 mumol/min per gkwt, respectively, as renal perfusion pressure was increased from 85 to 146 mm Hg. Renal blood flow and glomerular filtration rate were autoregulated and averaged 7.5 and 1.2 mL/min per gkwt. In untreated SBN/y with controlled neural and circulating factors, pressure-diuresis and -natriuresis curves were shifted toward the right, and renal blood flow and glomerular filtration rate ranged between 4.2 and 9.1 or 1 and 1.3 mL/min per gkwt as perfusion pressure was increased f...Continue Reading

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Citations

Jan 5, 2000·Kidney International·V GrossF C Luft
Jan 3, 2001·Kidney International·V M VehaskariJ Manning
Nov 14, 1997·Kidney International·V GrossF C Luft
Sep 13, 2005·Pharmacology & Therapeutics·Francisco J López-Hernández, José M López-Novoa
Jul 21, 2015·PloS One·Patrick Osei-OwusuKendall J Blumer
Aug 5, 2000·American Journal of Physiology. Renal Physiology·C T WangL G Navar

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