Pressurized CO2 as a carboxylating agent for the biocatalytic ortho -carboxylation of resorcinol

Green Chemistry : an International Journal and Green Chemistry Resource : GC
Katharina PlaschKurt Faber

Abstract

The utilization of gaseous carbon dioxide instead of bicarbonate would greatly facilitate process development for enzyme catalyzed carboxylations on a large scale. As a proof-of-concept, 1,3-dihydroxybenzene (resorcinol) was carboxylated in the ortho-position using pressurized CO2 (∼30-40 bar) catalyzed by ortho-benzoic acid decarboxylases with up to 68% conversion. Optimization studies revealed tight pH-control and enzyme stability as the most important determinants.

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Citations

Aug 6, 2019·Advanced Synthesis & Catalysis·Stefan E PayerSilvia M Glueck
Oct 23, 2020·Chembiochem : a European Journal of Chemical Biology·Gerhard HoferSilvia M Glueck
Feb 26, 2021·ChemSusChem·Godwin A AlekuDavid Leys
Jun 19, 2021·Computational and Structural Biotechnology Journal·Xiang Sheng, Fahmi Himo
Jun 13, 2019·Journal of the American Chemical Society·Iria BernhardsgrütterTobias J Erb

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