Prestimulation with recombinant human thyrotropin (rhTSH) improves the long-term outcome of radioiodine therapy for multinodular nontoxic goiter

The Journal of Clinical Endocrinology and Metabolism
Søren FastL Hegedüs

Abstract

The objective of the study was to evaluate the long-term outcome of recombinant human TSH (rhTSH)-augmented radioiodine ((131)I) therapy for benign multinodular nontoxic goiter. Between 2002 and 2005, 86 patients with a multinodular nontoxic goiter were treated with (131)I in two randomized, double-blind, placebo-controlled trials. (131)I-therapy was preceded by 0.3 mg rhTSH (n = 42) or placebo (n = 44). In 2009, 80 patients completed a follow-up (FU) visit, including determination of thyroid volume, thyroid function, and patient satisfaction by a visual analog scale. In both groups, thyroid volume was further reduced from 1 yr to final FU (71 months). The mean goiter volume reductions obtained at 1 yr and final FU [59.2 ± 2.4% (sem) and 69.7 ± 3.1%, respectively] in the rhTSH group were significantly greater than those obtained in the (131)I-alone group (43.2 ± 3.7 and 56.2 ± 3.6%, respectively, P = 0.001 and P = 0.006), corresponding to a gain of 24% at final FU. At last FU the mean reduction in compression visual analog scale score was significantly greater in patients receiving rhTSH (P = 0.049). Additional therapy (thyroid surgery or (131)I) was required more often in the placebo group (nine of 44) compared with the rhTSH ...Continue Reading

References

Sep 10, 1988·BMJ : British Medical Journal·L HegedüsJ M Hansen
Feb 1, 1983·The Journal of Clinical Endocrinology and Metabolism·L HegedüsJ M Hansen
Oct 2, 1993·BMJ : British Medical Journal·B NygaardJ M Hansen
Sep 1, 1999·Clinical Endocrinology·R Le MoliW M Wiersinga
Mar 10, 2001·The Journal of Clinical Endocrinology and Metabolism·M F WescheW M Wiersinga
Nov 10, 2001·The Journal of Clinical Endocrinology and Metabolism·W A NieuwlaatD A Huysmans
Feb 18, 2003·Endocrine Reviews·Laszlo HegedüsFinn N Bennedbaek
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Viveque E NielsenLaszlo Hegedüs
Feb 17, 2005·The Journal of Clinical Endocrinology and Metabolism·C C AlbinoH Graf
Mar 25, 2006·European Journal of Endocrinology·Torquil WattUlla Feldt-Rasmussen
Jul 31, 2008·The Journal of Clinical Endocrinology and Metabolism·Steen J BonnemaLaszlo Hegedüs
May 1, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Søren FastLaszlo Hegedüs
Jul 23, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Steen J Bonnema, Laszlo Hegedüs
Oct 3, 2009·European Journal of Endocrinology·Torquil WattUlla Feldt-Rasmussen
Apr 20, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C C AlbinoC Buchpiguel
May 26, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hossein GharibUNKNOWN AACE/AME/ETA Task Force on Thyroid Nodules

❮ Previous
Next ❯

Citations

Sep 29, 2012·The Journal of Clinical Endocrinology and Metabolism·Marvin C Gershengorn, Susanne Neumann
Dec 4, 2013·Thyroid : Official Journal of the American Thyroid Association·Amy Y ChenAshok R Shaha
Jul 23, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Steen Joop BonnemaLaszlo Hegedüs
Jul 17, 2016·Revista española de medicina nuclear e imagen molecular·M J Azorín BeldaJ Verdú Rico
Aug 3, 2016·Nuklearmedizin. Nuclear Medicine·Limin TangFengyu Wu
Jan 23, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Roberto NegroRoberto Valcavi
May 12, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hossein GharibUNKNOWN AACE/ACE/AME Task Force on Thyroid Nodules
Aug 21, 2019·Annales d'endocrinologie·Pierre Bel LassenBernard Corvilain

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.