Prestimulus functional connectivity determines pain perception in humans.

Proceedings of the National Academy of Sciences of the United States of America
Markus PlonerIrene Tracey

Abstract

Pain is a highly subjective experience that can be substantially influenced by differences in individual susceptibility as well as personality. How susceptibility to pain and personality translate to brain activity is largely unknown. Here, we report that the functional connectivity of two key brain areas before a sensory event reflects the susceptibility to a subsequent noxious stimulus being perceived as painful. Specifically, the prestimulus connectivity among brain areas related to the subjective perception of the body and to the modulation of pain (anterior insular cortex and brainstem, respectively) determines whether a noxious event is perceived as painful. Further, these effects of prestimulus connectivity on pain perception covary with pain-relevant personality traits. More anxious and pain-attentive individuals display weaker descending connectivity to pain modulatory brain areas. We conclude that variations in functional connectivity underlie personality-related differences in individual susceptibility to pain.

References

Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
Nov 5, 1997·NeuroImage·K J FristonR J Dolan
Sep 28, 1998·The European Journal of Neuroscience·C van der TogtH Spekreijse
Jun 18, 1999·Science·A PloghausJ N Rawlins
Jan 29, 2000·Nature Neuroscience·A D CraigE M Reiman
Feb 9, 2002·Science·Predrag PetrovicMartin Ingvar
Jun 8, 2002·Annual Review of Neuroscience·Karl Friston
Jun 20, 2003·NeuroImage·R DeichmannR Turner
Dec 18, 2003·Neurophysiologie clinique = Clinical neurophysiology·L Plaghki, A Mouraux
Feb 21, 2004·Science·Tor D WagerJonathan D Cohen
Mar 31, 2004·NeuroImage·Mark W WoolrichStephen M Smith
Nov 24, 2004·Pharmaceutical Research·Barbara G StubbeJoseph Demeester
Jun 2, 2005·Pain·Geert CrombezChristopher Eccleston
Jun 28, 2005·European Journal of Pain : EJP·A Vania ApkarianJon-Kar Zubieta
Sep 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Tetsuo KoyamaRobert C Coghill
Oct 29, 2005·The Journal of Comparative Neurology·Hugo D Critchley
Nov 16, 2005·Nature Neuroscience·Victor de Lafuente, Ranulfo Romo
Nov 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ayelet SapirMaurizio Corbetta
Jun 13, 2006·Nature Neuroscience·D H WeissmanM G Woldorff
Jun 20, 2006·Biological Psychiatry·Martin P Paulus, Murray B Stein
Nov 25, 2006·Science·Christopher SummerfieldJoy Hirsch
Jul 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·M BolyS Laureys
Aug 7, 2007·Neuron·Irene Tracey, Patrick W Mantyh
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
May 10, 2008·Nature Reviews. Neuroscience·Hauke R HeekerenLeslie G Ungerleider
Jul 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Guido HesselmannAndreas Kleinschmidt
Oct 1, 2008·Trends in Neurosciences·Gustavo Deco, Ranulfo Romo
Dec 20, 2008·Nature Reviews. Neuroscience·A D Bud Craig
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher J StarrRobert C Coghill

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Citations

Jun 26, 2013·British Journal of Anaesthesia·M C Lee, I Tracey
Aug 18, 2010·Cerebral Cortex·Markus PlonerIrene Tracey
Mar 8, 2011·Cerebral Cortex·Enrico SchulzMarkus Ploner
Jul 6, 2012·Cerebral Cortex·Daniel W GrupeJack B Nitschke
Nov 3, 2010·The Journal of Clinical Investigation·Petra Schweinhardt, M Catherine Bushnell
Oct 1, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lauren Y AtlasTor D Wager
Jan 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tor D WagerJames K Rilling
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wako YoshidaRaymond J Dolan
Oct 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Aaron KucyiKaren D Davis
Jan 30, 2014·Nature Neuroscience·Franziska DenkIrene Tracey
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Nathan WeiszChristoph Braun
Jun 24, 2014·Radiology·Frederik BarkhofSerge A R B Rombouts
Sep 9, 2011·Der Schmerz·A Otti, M Noll-Hussong
Jun 12, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Carl Saab
Jul 25, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Karen D Davis, Massieh Moayedi
May 25, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·P CortelliG Pierangeli
Feb 14, 2016·Cerebral Cortex·Aaron KucyiEve M Valera
Jun 25, 2015·Proceedings of the National Academy of Sciences of the United States of America·Sepideh SadaghianiMark D'Esposito
May 20, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Claire E WilcoxPaul G Mullins
Jul 6, 2012·Trends in Neurosciences·Carl Y Saab
Mar 27, 2012·Neuroscience Letters·Scott J Thompson, M Catherine Bushnell
Sep 6, 2011·The Psychiatric Clinics of North America·Stuart W G Derbyshire
Mar 16, 2011·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Sue M HaddenTerri Voepel-Lewis
Mar 8, 2011·Behavioural Brain Research·Clas LinnmanMohammed R Milad
Dec 27, 2011·NeuroImage·Clas LinnmanDavid Borsook
Dec 20, 2011·Arthritis and Rheumatism·A SoniN K Arden
Jun 18, 2011·Human Brain Mapping·Bruno G OertelJörn Lötsch
Jan 23, 2014·Arthritis & Rheumatology·Marco L LoggiaVitaly Napadow
Apr 2, 2014·European Journal of Pain : EJP·B BaierM Dieterich
Oct 18, 2014·Human Brain Mapping·Eva-Maria SeidelClaus Lamm

❮ Previous
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