PMID: 8601853Mar 1, 1996Paper

Prestorage versus bedside white blood cell filtration of red blood cell concentrates: effects on the content of cytokines and soluble tumor necrosis factor receptors

The Journal of Trauma
M KristianssonK G Sundqvist

Abstract

The cytokine network has important implications for the systemic inflammatory and metabolic response in trauma and infection. The objective of this study was to investigate the influence of white blood cell (WBC) filtration on the cytokine content in red blood cell concentrates (RBCs). Tumor necrosis factor-alpha (TNF), interleukin-1-beta (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), and soluble TNF receptors I and II (sTNF-RI, sTNF-RII) were investigated in filtered and nonfiltered RBCs during storage. After 40 days of storage the originally nonfiltered units were filtered. On day 1 prestorage filtered RBCs had lower concentrations of WBCs (p < 0.001), TNF (p < 0.01), sTNF-RI (p < 0.01) and sTNF-RII (p < 0.05) compared to nonfiltered units. IL-1 concentrations increased from day 1 to day 40 (p < 0.05) in nonfiltered RBCs and were higher in nonfiltered units compared to prestorage filtered ones on day 40 (p < 0.05). An increase of IL-8 was found in nonfiltered RBCs as well as prestorage filtered units from day 1 to day 40 (p < 0.05) but the concentrations of IL-8 were higher in nonfiltered units on day 40 compared to prestorage filtered units (p < 0.05). Filtration at the end of the 40-day storage ...Continue Reading

References

Dec 21, 1978·The New England Journal of Medicine·C F HögmanH Zetterström
Jan 1, 1992·Progress in Growth Factor Research·D RennickG Holland
Apr 1, 1992·Immunology Today·N Hogg
Sep 1, 1991·Cytokine·A Zlotnik, K W Moore
Nov 1, 1991·Immunology Today·C A Dinarello, R C Thompson
Oct 1, 1991·The Journal of Clinical Investigation·W C DarbonneJ B Baker
May 1, 1990·Immunology Today·K BendtzenE Hippe
Dec 1, 1989·Archives of Surgery·H R FordR L Simmons
May 1, 1988·The Journal of Experimental Medicine·P PeveriM Baggiolini
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Jun 27, 1983·Annals of the New York Academy of Sciences·D G Ritchie, G M Fuller
Jul 1, 1995·The Journal of Infectious Diseases·B GårdlundB Wretlind
Jul 1, 1994·Transfusion Medicine Reviews·R D Davenport, S L Kunkel
Jan 1, 1993·Intensive Care Medicine·M KristianssonK G Sundqvist
Jan 1, 1993·Annual Review of Cell Biology·K J Tracey, A Cerami
Jun 1, 1993·Critical Care Medicine·R C HochE Abraham
May 8, 1994·Transfusion Science·S Dzik

❮ Previous
Next ❯

Citations

May 7, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Dean FergussonPaul C Hébert
Sep 4, 2008·Journal of Thrombosis and Thrombolysis·Vijayalakshmi KunadianC Michael Gibson
Jul 31, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Tushar D MahambreyNeill K J Adhikari
May 16, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Joel M BaumgartnerMartin D McCarter
Jan 16, 2004·Critical Care Medicine·Juliet HoIan H Chin-Yee
Apr 25, 2008·Critical Care Medicine·Timothy R WatkinsAvery B Nathens
Feb 21, 2009·Journal of the American College of Surgeons·Joel M BaumgartnerMartin D McCarter
Oct 13, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Maria TylmanAnders Bengtsson
Aug 11, 2000·Evolution; International Journal of Organic Evolution·T R Birkhead
Jul 25, 2009·Transfusion·Ian H Chin-YeeChristopher G Ellis
Feb 10, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Azza A Aboul EneinMaha H El Sissy
Nov 11, 2008·Biochimica Et Biophysica Acta·Caroline P Ozment, Jennifer L Turi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.