PMID: 7540874Apr 1, 1995Paper

Presumed central nervous system Whipple's disease in a child: case report

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
T Q TanS L Kaplan

Abstract

Whipple's disease is a rare, chronic, multisystem illness that is pathologically characterized by the accumulation of macrophages in the involved tissue that have a positive periodic acid-Schiff reaction. It is typically seen in middle-aged white men, and only four cases involving persons younger than 15 years of age have been reported. CNS Whipple's disease without intestinal manifestations is rare; only six cases have been reported in the literature, all involving adults. We report the case of a young boy with clinical, laboratory, radiographic, and pathological signs and symptoms consistent with CNS Whipple's disease who responded to therapy with trimethoprimsulfamethoxazole.

Citations

Oct 21, 2003·Current Neurology and Neuroscience Reports·Elan D Louis
Mar 11, 2000·Neuromuscular Disorders : NMD·T R HelliwellK P Walsh
Jul 4, 2001·Clinical Microbiology Reviews·F Dutly, M Altwegg
Oct 31, 2002·Journal of Neurosurgery·Ziya AkarCengiz Kuday
Jun 13, 2015·Revista brasileira de reumatologia·Guilherme Almeida Rosa da Silva, José Soares Pires Neto
Feb 27, 2003·The European Journal of Neuroscience·Rafael Cernuda-CernudaWillem J DeGrip
Jul 3, 2020·Intestinal research·Maiko TatsukiHirokazu Arakawa

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