Presumed primary orbital neuroblastoma in a 20-month-old female

Ophthalmic Plastic and Reconstructive Surgery
Nanfei Zhang, Lily Koo Lin

Abstract

Neuroblastoma is the most common malignant disease of childhood, and it often arises from either the adrenal gland or along the sympathetic chain. The authors report a case of a 20-month-old female with a presumed primary neuroblastoma of the orbit. Radiologically, the tumor showed a brightly enhancing mass lesion of the left side with intraorbital, temporal extraorbital, transsphenoid, and intracranial components. Histopathologically, the tumor was composed of small round blue cells. Immunohistochemical staining was positive for neuron-specific enolase. To the best of the authors' knowledge, primary orbital neuroblastoma has only been previously reported once in children, although it has been reported twice in adults.

References

Jul 1, 1989·Archives of Ophthalmology·J D BullockP J Connelly
Mar 1, 1987·Ophthalmology·F A JakobiecT C Spoor
May 30, 2003·The Oncologist·Joanna L WeinsteinSusan L Cohn
Aug 22, 2006·Indian Journal of Ophthalmology·Hasan MirzaiAydin Isisag

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Citations

Jun 16, 2014·Survey of Ophthalmology·Benjamin P Erickson, David T Tse
Nov 19, 2015·Indian Journal of Ophthalmology·Muthukrishnan VallinayagamNiruban Ganesan
Jul 10, 2020·BMJ Case Reports·Renu P RajanKim Ramasamy
Aug 6, 2021·Laryngo- rhino- otologie·Ulrich KisserAlexander Glien

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