Presumed "sulfa allergy" in patients with intracranial hypertension treated with acetazolamide or furosemide: cross-reactivity, myth or reality?

American Journal of Ophthalmology
Andrew G LeeMichael Wall

Abstract

To determine whether acetazolamide or furosemide produce allergic cross-reactions in patients with self-reported "sulfa allergy." Retrospective case series. A retrospective review included patients with intracranial hypertension and a self-reported sulfa allergy treated with either acetazolamide or furosemide seen at the University of Iowa Hospitals and Clinics from 1972 to 2003. All presumed medication-related side effects were collected, including both predictable adverse effects (for example, paresthesias, fatigue) and unpredictable adverse reactions (for example, cutaneous fixed eruptions, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, anaphylaxis). We reviewed 363 charts. Of these, 329 patients (91%) were excluded. Of the remaining 34 cases that did report a so-called sulfa allergy, 13 (38%) received acetazolamide alone, 7 (21%) received furosemide alone, and 14 (41%) received both acetazolamide and furosemide. Of the 27 patients who received acetazolamide, 10 (37%) had no documented allergic cross-reaction to sulfa, and 2 (7%) cases had urticaria. The remaining 15 (56%) of acetazolamide-treated patients experienced predictable adverse reactions for this drug (for example, paresthesias). No pa...Continue Reading

References

Dec 22, 1975·JAMA : the Journal of the American Medical Association·F E Karch, L Lasagna
Sep 15, 1992·American Journal of Ophthalmology·J PeraltaJ Fernández-Guardiola
Jan 2, 1991·JAMA : the Journal of the American Medical Association·T J Sullivan
May 1, 1990·Archives of Ophthalmology·J G Stock
Oct 1, 1987·The Journal of Allergy and Clinical Immunology·J R HansbroughD D Chaplin
May 1, 1967·The British Journal of Ophthalmology·A Kristinsson
Jan 25, 2000·Clinical Therapeutics·R PattersonJ Lefkowith
Feb 7, 2001·Anaesthesia·C S Dwenger
May 2, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·S KnowlesN H Shear
Oct 24, 2003·The New England Journal of Medicine·Brian L StromDan Pettitt

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Citations

Dec 14, 2011·Archives of Neurology·Daniel Platt, Robert C Griggs
Nov 11, 2010·Current Treatment Options in Neurology·Melissa W Ko
Mar 7, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Donald A Dibbern, Anthony Montanaro
Mar 1, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Guilherme B GuedesM Bruce Shields
May 2, 2012·BMC Research Notes·Radhika KumarJames Chodosh
Jan 11, 2014·AJNR. American Journal of Neuroradiology·P G KranzL Gray
Dec 31, 2010·High Altitude Medicine & Biology·Thomas E Kelly, Peter H Hackett
Jun 26, 2012·High Altitude Medicine & Biology·Bengt KayserMartin R Tramèr
Mar 13, 2014·Expert Opinion on Drug Safety·Erik R Swenson
Nov 21, 2015·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Martin W ten HoveUNKNOWN NORDIC Idiopathic Intracranial Hypertension Study Group
Apr 8, 2014·Neurologic Clinics·Deborah I Friedman
Jul 20, 2010·Neurologic Clinics·Michael Wall
Jun 19, 2007·La Presse médicale·Amélie DaveluyFrançoise Haramburu
Nov 7, 2006·Immunology and Allergy Clinics of North America·Paul A Greenberger
May 17, 2007·Internal Medicine Journal·W B Smith, R J Mullins
Apr 25, 2008·Seminars in Ophthalmology·Ronald HammersWalter M Jay
Jan 17, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Asal GharibSyeda T Hamadani
Sep 25, 2017·Chemical Biology & Drug Design·Fatemeh Mohammadipanah, Fatemeh Salimi
Apr 8, 2018·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Megan A Van Berkel, Jessica L Elefritz
Aug 15, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Nicole R Wulf, Karl A Matuszewski
Oct 22, 2008·International Ophthalmology Clinics·Casey C Geringer, Nauman R Imami
May 23, 2017·Current Ophthalmology Reports·Thasarat S VajaranantAhmad A Aref
Dec 15, 2005·The Annals of Pharmacotherapy·Paul JuangRonald Zolty
Jul 1, 2018·Ophthalmology and Therapy·Tirth J ShahPhillip C Hoopes
Sep 4, 2019·Expert Review of Neurotherapeutics·Deborah I Friedman
Jun 8, 2018·Current Allergy and Asthma Reports·Joshua M DornGerald W Volcheck

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