PMID: 6406399Apr 1, 1983Paper

Presumptive downstaging from preoperative irradiation for bladder cancer as determined by flow cytometry: preliminary report

International Journal of Radiation Oncology, Biology, Physics
F A KleinM R Melamed

Abstract

Presumptive tumor downstaging was evaluated in 28 patients with grade II or III, solid, muscle-infiltrating bladder cancer (clinical category T3) treated by integrated irradiation (2000 rad to the whole pelvis in 5 days) and cystectomy (1-14 days later) by comparing the results of flow cytometry (FCM) on barbotage specimens obtained before and after irradiation (at the time of cystectomy) and the results of pretreatment clinical stage (T category) and post cystectomy pathological stage (P category). The patients were divided into three groups: (1) P greater than T, (2) P = T, and (3) P less than T. All of the patients in this study had positive FCM specimens with an aneuploid stemline in the pre-irradiation specimen. A complete radiation response (CRR) was defined by FCM as disappearance of the aneuploid stem cell line. Of the 5 patients in the P less than T group, 4 showed a CRR; of 20 patients in the P = T group, 8 showed a CRR; of the 3 patients in the P greater than T group, none showed a CRR. The proportion of patients in the various T/P groups is consistent with that previously observed in patients receiving integrated irradiation (2000 rad in 5 days) and cystectomy (1-14 days later). The overall downstaging response of 4...Continue Reading

References

Oct 1, 1975·Experimental Cell Research·Z DarzynkiewiczM R Melamed
Jan 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L CollsteM R Melamed
Mar 1, 1979·International Journal of Radiation Oncology, Biology, Physics·B van der Werf-Messing

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Citations

Sep 1, 1992·Seminars in Surgical Oncology·M R Melamed
Feb 15, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·D H RyanP K Horan
Oct 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A B JacobsenE O Pettersen
Jan 3, 1996·International Journal of Cancer. Journal International Du Cancer·M KarlssonS Wingren
Sep 6, 2002·Oncogene·Stéphanie DutertreClaude Prigent

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