Presumptive hepatotoxicity and rhabdomyolysis secondary to phenazopyridine toxicity in a dog

Journal of Veterinary Emergency and Critical Care
Melissa L HolahanCristine L Hayes

Abstract

To describe a rare, but potential clinical manifestation of phenazopyridine (PAP) toxicity in a dog. A 6-year-old spayed female Chihuahua was evaluated for ataxia and dysphagia after ingestion of 200 mg (66 mg/kg) of PAP hydrochloride. The dog was presented to the hospital with shifting leg lameness involving all 4 limbs, which progressed to reluctance to walk and severe diffuse muscle hyperesthesia. Clinical laboratory abnormalities included marked increases in serum alanine aminotransferase, aspartate aminotransferase, creatine kinase, mild increases in alkaline phosphatase, and increased c-Tnl-troponin concentration. Treatment included administration of intravenous fluids, muscle relaxants, pain medications, and hepatoprotectants for 5 days in the hospital, and medical management at home for an additional 5 days. Follow-up examinations performed 1 and 6 months after initial presentation revealed the dog to be clinically healthy with serum biochemical profiles within reference intervals. The purpose of this report is to describe an unusual manifestation of PAP toxicosis in a dog, which has not been previously reported in the literature. A review of the ASPCA Animal Poison Control Center database revealed 347 cases of PAP expo...Continue Reading

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Citations

Jul 8, 2014·Blood Cells, Molecules & Diseases·Vera GaunPaula G Fraenkel
Apr 18, 2015·Journal of Veterinary Emergency and Critical Care·Molly A Weingarten, Allison A Sande
Jan 10, 2017·The Veterinary Clinics of North America. Small Animal Practice·Vincent Thawley
Dec 7, 2018·Journal of Veterinary Emergency and Critical Care·Christine GriebschPeter Bennett
Aug 28, 2021·Journal of Veterinary Emergency and Critical Care·Marcella Granfone, Julie M Walker

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