Presurgical thalamic "hubness" predicts surgical outcome in temporal lobe epilepsy

Neurology
Xiaosong HeJoseph I Tracy

Abstract

To characterize the presurgical brain functional architecture presented in patients with temporal lobe epilepsy (TLE) using graph theoretical measures of resting-state fMRI data and to test its association with surgical outcome. Fifty-six unilateral patients with TLE, who subsequently underwent anterior temporal lobectomy and were classified as obtaining a seizure-free (Engel class I, n = 35) vs not seizure-free (Engel classes II-IV, n = 21) outcome at 1 year after surgery, and 28 matched healthy controls were enrolled. On the basis of their presurgical resting-state functional connectivity, network properties, including nodal hubness (importance of a node to the network; degree, betweenness, and eigenvector centralities) and integration (global efficiency), were estimated and compared across our experimental groups. Cross-validations with support vector machine (SVM) were used to examine whether selective nodal hubness exceeded standard clinical characteristics in outcome prediction. Compared to the seizure-free patients and healthy controls, the not seizure-free patients displayed a specific increase in nodal hubness (degree and eigenvector centralities) involving both the ipsilateral and contralateral thalami, contributed by...Continue Reading

References

Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Aug 4, 2001·The New England Journal of Medicine·S WiebeUNKNOWN Effectiveness and Efficiency of Surgery for Temporal Lobe Epilepsy Study Group
Jan 16, 2002·Archives of Neurology·Hal Blumenfeld
Jul 16, 2003·Epilepsia·Philippe Ryvlin
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jun 9, 2006·Brain : a Journal of Neurology·Maxime GuyeFabrice Bartolomei
Sep 22, 2006·Neurology·J I TracyD Glosser
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Apr 12, 2008·Cerebral Cortex·Michael D GreiciusRobert F Dougherty
May 20, 2008·Lancet Neurology·Susan Spencer, Linda Huh
Sep 12, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Danielle S BassettAndreas Meyer-Lindenberg
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·C J HoneyP Hagmann
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Jan 9, 2010·Nature Reviews. Neurology·Dongyang Zhang, Marcus E Raichle
Oct 30, 2010·Frontiers in Systems Neuroscience·Aaron F Alexander-BlochEdward T Bullmore
Mar 1, 2012·Annals of Neurology·Maeike ZijlmansJean Gotman
Jan 30, 2015·Annals of Neurology·Simon S KellerBernd Weber
Feb 24, 2015·Nature Reviews. Neuroscience·Alex FornitoMichael Breakspear
Jul 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Chun-Yi Zac LoEdward T Bullmore

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Citations

Jan 25, 2018·Brain : a Journal of Neurology·Christopher D WhelanSanjay M Sisodiya
Jul 25, 2018·Epilepsia·Patrizia AracriLaura Uva
Dec 21, 2019·Brain : a Journal of Neurology·Xiaosong HeMichael R Sperling
May 19, 2017·Neurology·Barbara C Jobst, Gregory D Cascino
Apr 25, 2020·Human Brain Mapping·Rachel RolinskiWilliam H Theodore
Aug 31, 2020·Epilepsia·Adriana M WorkewychGeorge M Ibrahim
Jan 24, 2018·Journal of Neurophysiology·George M IbrahimAndres A Lozano
Aug 15, 2018·Brain : a Journal of Neurology·Stanislas LagardeFabrice Bartolomei
May 20, 2020·Communications Biology·Yifei WengBoris C Bernhardt
Jul 14, 2018·Nature Reviews. Neuroscience·Danielle S BassettJoshua I Gold
Aug 14, 2019·Annals of Clinical and Translational Neurology·Andrew RomeoSandipan Pati
Jul 26, 2019·Nature Reviews. Neurology·Maeike ZijlmansNicole van Klink
Jun 15, 2019·Journal of Neurosurgery·Victoria L MorganDario J Englot
Dec 14, 2018·Frontiers in Neuroscience·Mohsen MazrooyisebdaniVivek Prabhakaran
Mar 1, 2019·Nature Communications·F PizzoC G Bénar
May 21, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Stanislas LagardeEric Guedj
Oct 6, 2020·Epilepsy Currents·Jerzy P Szaflarski
Aug 28, 2020·Neurology·Lorenzo CaciagliMichael R Sperling
Nov 26, 2020·Epilepsia·Sara LarivièreBoris C Bernhardt
Feb 10, 2021·Epilepsy Currents·Neda Bernasconi, Irene Wang
Oct 16, 2020·Acta Neurologica Scandinavica·Wei LiDongmei An
Mar 21, 2020·NeuroImage·Hannelore AertsDaniele Marinazzo
Feb 6, 2020·Seizure : the Journal of the British Epilepsy Association·Elliot G NealFernando L Vale
Jan 28, 2020·Seizure : the Journal of the British Epilepsy Association·Ho-Joon Lee, Kang Min Park
May 5, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Adam M Goodman, Jerzy P Szaflarski
Jul 10, 2021·Frontiers in Neuroscience·Daichi Sone, Iman Beheshti
Aug 20, 2021·Frontiers in Neurology·Rory J PiperDavid W Carmichael
Jul 3, 2021·Brain Connectivity·Kiwamu KudoSrikantan S Nagarajan
Sep 11, 2021·Epilepsy & Behavior : E&B·Eliot D SmolyanskyPatrick Kwan
Sep 23, 2021·Journal of Neurophysiology·Olivia N ArskiGeorge M Ibrahim

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