Abstract
A 62-year-old man presented with bilateral diffuse uveal melanocytic proliferations (BDUMP) and painful flexor contractures of the fingers of both hands. All these features were considered paraneoplastic but extensive and repeated investigations revealed no underlying malignancy. Oral steroids and orbital radiotherapy were ineffective. The diagnosis was confirmed by trans-scleral biopsy of the right choroid. Rapidly progressive cataracts were treated by phacoemulsification. Severe exudative retinal detachment with rubeosis and neovascular glaucoma in the left eye were treated successfully by partial choroidectomy. Fifteen months after presentation, investigations detected a 22 mm, poorly differentiated adenocarcinoma, which was resected without complication. The ocular tumours in both eyes regressed, without improvement in vision of Light Perception, and the palmar fasciitis also improved. The patient remained free of tumour recurrence until sudden death from myocardial infarction five years after he first presented.
References
Nov 1, 1991·The British Journal of Ophthalmology·J D Gass, R J Glatzer
Jul 15, 1990·American Journal of Ophthalmology·J M RohrbachH J Thiel
Apr 1, 1990·Archives of Ophthalmology·J D GassS E Pautler
Jan 1, 1986·The British Journal of Ophthalmology·S TsukaharaS Ohzeki
Jun 1, 1994·The British Journal of Ophthalmology·C M MooyC Strous
Jun 26, 1998·Clinical Rheumatology·E M EekhoffF C Breedveld
Feb 15, 2001·The American Journal of Surgical Pathology·F ChahudT P Dryja
Nov 12, 2003·Survey of Ophthalmology·Kevin D O'NealAlan D Proia
Citations
Jul 30, 2011·Eye·G De SalvoA J Lotery
Jun 22, 2013·Eye·J S PulidoD R Salomao
Nov 21, 2007·The British Journal of Ophthalmology·Shantan Reddy, Paul T Finger
Apr 2, 2014·Seminars in Arthritis and Rheumatism·Bernhard Manger, Georg Schett
Aug 24, 2013·Survey of Ophthalmology·Ehsan Rahimy, David Sarraf
Sep 16, 2015·Internal Medicine·Shoichi FukuiNobuaki Funata
Jul 22, 2008·Veterinary Ophthalmology·Simon M Petersen-JonesMatti Kiupel
Jul 6, 2014·Ocular Immunology and Inflammation·Zaid ShalchiMoin Mohamed
May 24, 2014·BMJ Case Reports·Salah AlrashidiHatem Krema
Mar 22, 2014·Retina·Dilraj S GrewalLee M Jampol
Nov 30, 2016·International Ophthalmology Clinics·Tomas A Moreno, Shriji N Patel
Aug 13, 2014·World Journal of Clinical Oncology·Nobuhiro KanajiTakuya Matsunaga
Dec 29, 2007·Current Opinion in Ophthalmology·Talal Alabduljalil, Raed Behbehani
Jan 26, 2016·Retinal Cases & Brief Reports·Azadeh GolshahiUlrich Kellner
Apr 1, 2013·Retinal Cases & Brief Reports·Juan Verdaguer, Jorge Oporto
Nov 17, 2016·International Journal of Retina and Vitreous·Jonathan NaysanK Bailey Freund
Dec 29, 2007·Current Opinion in Ophthalmology