Presymptomatic Screening for Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease

Clinical Journal of the American Society of Nephrology : CJASN
Irina M SanchisVicente E Torres

Abstract

Intracranial aneurysm rupture is the most devastating complication of autosomal dominant polycystic kidney disease. Whether selective or widespread intracranial aneurysm screening is indicated remains controversial. Records of 3010 patients with autosomal dominant polycystic kidney disease evaluated at the Mayo Clinic between 1989 and 2017 were reviewed. Those who had presymptomatic magnetic resonance angiography screening were included. Ninety-four intracranial aneurysms were diagnosed in 75 of 812 (9%) patients who underwent magnetic resonance angiography screening. Sex, age, race, and genotype were similar in the groups with and without aneurysms; hypertension and history of smoking were more frequent in the aneurysm group. Twenty-nine percent of patients with aneurysms compared with 11% of those without aneurysms had a family history of subarachnoid hemorrhage (P<0.001). Most aneurysms were small (median diameter =4 mm; range, 2-12 mm); 85% were in the anterior circulation. During a total imaging follow-up of 469 patient-years, de novo intracranial aneurysms were detected in five patients; eight intracranial aneurysms grew (median =2 mm; range, 1-3 mm). During a total clinical follow-up of 668 patient-years, seven patients ...Continue Reading

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Citations

Jan 13, 2021·Néphrologie & thérapeutique·Mouad HamzaouiDominique Guerrot
May 12, 2021·Cardiovascular Research·Mannekomba R DiagbougaBrenda R Kwak
Sep 30, 2021·Clinical Neuroradiology·I CapelliG La Manna
Nov 28, 2020·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Covadonga López Del Moral CuestaGema Fernández Fresnedo

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