Presymptomatic Treatment With Andrographolide Improves Brain Metabolic Markers and Cognitive Behavior in a Model of Early-Onset Alzheimer's Disease

Frontiers in Cellular Neuroscience
Pedro CisternasNibaldo C Inestrosa

Abstract

Alzheimer's disease (AD) is the most common type of dementia. The onset and progression of this pathology are correlated with several changes in the brain, including the formation of extracellular aggregates of amyloid-beta (Aβ) peptide and the intracellular accumulation of hyperphosphorylated tau protein. In addition, dysregulated neuronal plasticity, synapse loss, and a reduction in cellular energy metabolism have also been described. Canonical Wnt signaling has also been shown to be downregulated in AD. Remarkably, we showed previously that the in vivo inhibition of Wnt signaling accelerates the appearance of AD markers in transgenic (Tg) and wild-type (WT) mice. Additionally, we found that Wnt signaling stimulates energy metabolism, which is critical for the ability of Wnt to promote the recovery of cognitive function in AD. Therefore, we hypothesized that activation of canonical Wnt signaling in a presymptomatic transgenic animal model of AD would improve some symptoms. To explore the latter, we used a transgenic mouse model (J20 Tg) with mild AD phenotype expression (high levels of amyloid aggregates) and studied the effect of andrographolide (ANDRO), an activator of canonical Wnt signaling. We found that presymptomatic a...Continue Reading

References

Mar 1, 1989·Neurology·J E HamosD A Drachman
Jun 15, 2004·Experimental Cell Research·Alejandra R AlvarezNibaldo C Inestrosa
Jul 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea CaricasoleFerdinando Nicoletti
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Apr 16, 2005·Nature Reviews. Neuroscience·Lorenza Ciani, Patricia C Salinas
Dec 29, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael J SaganichStephen F Heinemann
Feb 14, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S Schinner
Aug 15, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ginny G FaríasNibaldo C Inestrosa
Dec 17, 2009·Nature Reviews. Neuroscience·Nibaldo C Inestrosa, Ernest Arenas
Jan 29, 2010·The New England Journal of Medicine·Henry W Querfurth, Frank M LaFerla
Sep 15, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lisa R StowBrian D Cain
Oct 20, 2010·Diabetes·José María Moreno-NavarreteJosé Manuel Fernández-Real
Nov 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lorena Varela-NallarNibaldo C Inestrosa
Jan 18, 2011·Current Opinion in Neurobiology·Vivian Budnik, Patricia C Salinas
Sep 24, 2011·Journal of Neuroscience Methods·Vassiliy TsytsarevLihong V Wang
Mar 9, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Silvia A PurroPatricia C Salinas
Mar 20, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·UNKNOWN Alzheimer's Association
Jan 23, 2014·Journal of Molecular Cell Biology·Silvia A PurroPatricia C Salinas
Jan 28, 2014·Journal of Neurochemistry·Pedro CisternasFrancisco Nualart
Feb 20, 2014·Journal of Molecular Cell Biology·Nibaldo C Inestrosa, Lorena Varela-Nallar
Apr 15, 2014·Cell Metabolism·Kristopher BurkewitzWilliam B Mair
Apr 16, 2014·Current Molecular Medicine·P CisternasN C Inestrosa
Aug 2, 2014·Progress in Neurobiology·Juvenal A RíosNibaldo C Inestrosa
Oct 2, 2014·Nature Reviews. Neuroscience·Howard Eichenbaum
Dec 20, 2014·Molecular Neurodegeneration·Felipe G SerranoNibaldo C Inestrosa
Aug 14, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea MegillHey-Kyoung Lee
Aug 25, 2015·Biochimica Et Biophysica Acta·Pedro CisternasNibaldo C Inestrosa
Oct 1, 2016·Annual Review of Psychology·Howard Eichenbaum
Oct 21, 2016·The Journal of Biological Chemistry·Pedro CisternasNibaldo C Inestrosa
Feb 6, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kevin ThurleyPål O Westermark
May 5, 2017·Neuron·Skyler L Jackman, Wade G Regehr
Jun 19, 2017·Neuroscience and Biobehavioral Reviews·Pedro Cisternas, Nibaldo C Inestrosa
Sep 30, 2017·Nature Reviews. Neurology·Jun WangYan-Jiang Wang
Feb 2, 2018·Progress in Molecular Biology and Translational Science·Carolina A OlivaNibaldo C Inestrosa

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Citations

Nov 9, 2019·Molecular Neurobiology·Carolina B LindsayNibaldo C Inestrosa
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Sebastian B ArredondoLorena Varela-Nallar
Oct 31, 2020·Journal of Neurochemistry·Camila GherardelliNibaldo C Inestrosa

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Methods Mentioned

BETA
transgenic
ELISA
Assay
electron microscopy

Software Mentioned

ANDRO
Prism
GraphPad
HVS Imagen
pClamp
SPSS

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