Presynapses go nuclear!

The EMBO Journal
Dana O Kravchick, Bryen A Jordan

Abstract

Decades of research has shown that long-term changes in synaptic function ultimately require changes in gene expression.Recent work has focused on nuclear signaling by calcium and protein messengers initiated at postsynaptic sites. In this issue of The EMBO Journal, Ivanova and colleagues show that shuttling of CtBP-1 between presynaptic areas and nuclei regulates gene expression, which reminds us that presynaptic zones should not be ignored when considering synapse-to nucleus signaling.

References

Jun 16, 2009·Trends in Neurosciences·Bryen A Jordan, Michael R Kreutz
Mar 30, 2010·Annual Review of Neuroscience·Michael P Coleman, Marc R Freeman
Dec 24, 2014·Trends in Neurosciences·Nicolas PanayotisMike Fainzilber

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Citations

Jan 23, 2016·Frontiers in Synaptic Neuroscience·Eckart D GundelfingerCraig C Garner
Jul 28, 2019·Neuromolecular Medicine·Yan Jun Lee, Toh Hean Ch'ng
Apr 27, 2016·Journal of Neuroscience Research·Arturo TozziJames F Peters

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