PMID: 8584511Aug 1, 1995Paper

Presynaptic alpha 2A-adrenoceptors regulate the 3H-noradrenaline secretion in the guinea-pig urethra

Pharmacology & Toxicology
P Alberts

Abstract

The subtype of the functional presynaptic autoreceptor in adrenergic nerves of the male guinea-pig urethra was pharmacologically characterised. The urethra was incubated with 3H-noradrenaline and superfused with Tyrode solution in vitro and the fractional secretion of 3H-noradrenaline evoked by 300 electrical shocks at 5 Hz was measured. alpha-Adrenoceptor antagonists enhanced the 3H-noradrenaline secretion. The effects of BRL 44408 ((+/-)-2-[(4,5-dihydro-1H-imidazol-2yl)methyl]-2,3- dihydro-1-methyl-1H-isoindole), BRL 41992 ((-)-1,2-dimethyl-2,3,9,13b-tetrahydro-1H-dibenzo[c,f]imidazo[1,5- a] azepine), and WB-4101 (2-([2,6-dimethoxyphenoxyethyl]aminomethyl)-1,4- benzodioxane) were tested. The rank order of apparent EC50 values was BRL 44408 < BRL 41992 < WB-4101, and correlated best with constants for the alpha 2A-C10/alpha 2A adrenoceptor subtype. The results suggest that 3H-noradrenaline secretion in guinea-pig urethra is regulated by a presynaptic adrenoceptor of the alpha 2A subtype.

References

Jul 1, 1992·Trends in Pharmacological Sciences·M BerlanM Lafontan
Dec 1, 1992·British Journal of Pharmacology·M RaiteriA Ruelle
Jul 1, 1989·Physiological Reviews·K StarkeH Kilbinger
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J W ReganB K Kobilka
Jan 1, 1993·General Pharmacology·P Alberts
Jul 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·A U TrendelenburgK Starke

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Citations

Nov 30, 2000·Scandinavian Journal of Urology and Nephrology·M C MonneronP Alberts
Aug 29, 2000·Scandinavian Journal of Urology and Nephrology·A R ModiriP Alberts
Jun 4, 1999·European Journal of Pharmacology·P AlbertsM G Fredrickson

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