PMID: 6108594Jan 1, 1980Paper

Presynaptic alpha-adrenoceptors and the action of tricyclic antidepressant drugs in behavioural despair in rats

Psychopharmacology
I Zebrowska-Lupina

Abstract

The influence of the alpha-adrenolytics, yohimbine and phentolamine, given in low doses thought to block presynaptic alpha-adrenoceptors, on the action of the tricyclic antidepressants imipramine, nortriptyline and amitriptyline in the behavioural despair test was investigated in Wistar rats. Antidepressant drugs given in a single dose or for 2 weeks reduced immobility in rats. Yohimbine potentiated the effect of nortriptyline or amitriptyline administered in a single dose and the effect of imipramine and amitriptyline given for 2 weeks. The potentiating effect of phentolamine was observed only in rats receiving a single dose of nortriptyline. Yohimbine given chronically for 3 weeks together with antidepressants counteracted the effect of imipramine and nortriptyline on behavioural despair. Similarly clonidine abolished the reduction of immobility induced by antidepressants given in a single dose. It is concluded that the despair test is a behavioural model which is sensitive to the noradrenergic component of the drugs and that the blockade of presynaptic alpha-adrenoceptors facilitates the action of tricyclic antidepressants in this test.

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Citations

Apr 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·A V Val'dmanV N Kalikhevich
Aug 1, 1987·Biulleten' eksperimental'noĭ biologii i meditsiny·V A ParshinN I Andreeva
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Jan 1, 1986·Neuroscience and Biobehavioral Reviews·S E File, J C Tucker
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Aug 2, 2007·Expert Opinion on Therapeutic Targets·Eric A Stone
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·B J Clark
Oct 3, 1999·Journal of Clinical Psychopharmacology·P Popik

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