Presynaptic and postsynaptic nigrostriatal dopaminergic functions in multiple system atrophy

Neuroreport
Masaya HashimotoKiyoharu Inoue

Abstract

A simultaneous evaluation of presynaptic and postsynaptic dopaminergic positron emission tomography markers, the dopamine transporters and the dopamine D2-like receptors, was performed in eight patients with parkinsonian phenotype of multiple system atrophy. Both presynaptic and postsynaptic markers were revealed to have declined in such a manner that they kept strong positive correlation throughout the striatum of all patients, suggesting that the degeneration process in the striatum may involve the entire structure of the dopaminergic synapse. In two L-3,4,dihydroxyphenyl-alanine-responsive cases, the balance of decline in two markers was relatively shifted to presynaptic dominant side. Correlative positron emission tomography study of presynaptic and postsynaptic dopaminergic function may be useful for the diagnosis of multiple system atrophy and to understand the mechanisms of its temporal L-3,4,dihydroxyphenyl-alanine responsiveness.

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Citations

Jul 25, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Kenji IshibashiKenji Ishii
Dec 8, 2009·Nuclear Medicine Communications·Kenji IshibashiKiichi Ishiwata
Dec 17, 2009·Acta Neurologica Scandinavica·K IshibashiK Ishii
Jul 16, 2010·Geriatrics & Gerontology International·Kiichi IshiwataJun Toyohara
Nov 22, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Takahiro SaitoKunihiro Isse
Mar 25, 2018·Acta Neurologica Scandinavica·L-L BuJ Wang
May 14, 2008·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Masahiro Mishina
May 19, 2018·Biomedical Reports·Miki NishimoriTakuji Yamagami

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