Presynaptic dopamine depletion determines the timing of levodopa-induced dyskinesia onset in Parkinson's disease

European Journal of Nuclear Medicine and Molecular Imaging
Han Soo YooPhil H Lee

Abstract

Reduced presynaptic dopaminergic activity plays an important role in the development of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD). In this study, we investigated whether dopaminergic function in the nigrostriatal system is associated with the timing of LID onset. From among 412 drug-naive PD patients who underwent a dopamine transporter (DAT) PET scan during their baseline evaluation, we enrolled 65 patients who developed LID during a follow-up period of >2 years. Based on the time from PD onset, LID was classified as early, intermediate or late onset. We then compared DAT availability in the striatal subregions of the patients in the three groups. The demographic characteristics did not differ among the three patient groups except for earlier intervention of levodopa therapy in the early LID onset group (p = 0.001). After adjusting for age at PD onset, gender, timing of levodopa therapy from PD onset, and the severity of PD motor symptoms, DAT activity in the posterior putamen was found to be significantly lower in the early LID onset group than in the late LID onset group (p = 0.017). Multivariate linear regression analysis showed that low DAT activity in the posterior putamen was significantly associated ...Continue Reading

References

Sep 1, 1989·Pharmacology, Biochemistry, and Behavior·J S Schneider
Jun 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·W R Gibb, A J Lees
Jan 1, 1987·Movement Disorders : Official Journal of the Movement Disorder Society·N QuinnC D Marsden
Jul 30, 1999·Journal of the Neurological Sciences·A P Denny, M Behari
May 16, 2000·Journal of Neural Transmission·R de la Fuente-FernándezA J Stoessl
Jun 1, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·D A Di MonteW J Langston
Oct 26, 2000·Brain : a Journal of Neurology·A Schrag, N Quinn
Aug 3, 2001·Nature Reviews. Neuroscience·E BezardC E Gross
Aug 29, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O MawlawiM Laruelle
Nov 26, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Anette SchragMarjan Jahanshahi
Dec 23, 2004·Journal of Neural Transmission·J M BrotchieK Venderova
Dec 6, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M PéchevisUNKNOWN Trial Study Group
Sep 1, 2006·Journal of Neurochemistry·M Angela Cenci, Martin Lundblad
Sep 8, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Olivier RascolUNKNOWN 056 Study Group
Apr 13, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Giovanni FabbriniChristopher G Goetz
May 24, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert B InnisRichard E Carson
Jul 10, 2007·Current Neurology and Neuroscience Reports·Theresa A ZesiewiczRobert A Hauser
Sep 2, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Michele TinazziAngelo Antonini
Sep 11, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Paolo CalabresiBarbara Picconi
Mar 5, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Anna BrückJuha O Rinne
Oct 5, 2010·Progress in Brain Research·Renju Kuriakose, A Jon Stoessl
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Jan 26, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Carsten EggersLars Timmermann
Jun 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Gregor K WenningEduardo Tolosa
Dec 23, 2011·Parkinsonism & Related Disorders·M M IravaniP Jenner
Feb 11, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Minyoung OhChong Sik Lee
Feb 7, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Mun Kyung SunwooPhil Hyu Lee
Dec 24, 2013·Neuroscience·N NevalainenI Strömberg
Feb 24, 2015·Neurobiology of Aging·Valtteri KaasinenMarko Seppänen
Mar 12, 2015·Journal of the Neurological Sciences·Philippe Huot

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Citations

Mar 11, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Giovanni PalermoRoberto Ceravolo
May 23, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Jin Ho JungPhil Hyu Lee
Oct 24, 2019·Annals of Clinical and Translational Neurology·Han Soo YooPhil Hyu Lee
Nov 28, 2018·NPJ Parkinson's Disease·Paolo EusebiLucilla Parnetti
Aug 14, 2019·Cells·Giovanni Palermo, Roberto Ceravolo
Sep 9, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Audrey MailletStéphane Thobois

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