Presynaptic dopaminergic function in patients with restless legs syndrome: are there common features with early Parkinson's disease?

Movement Disorders : Official Journal of the Movement Disorder Society
R LinkeK Tatsch

Abstract

The cause of restless legs syndrome (RLS) is unknown, but an involvement of the dopaminergic system and a possible relation to Parkinson's disease (PD) is suggested by the positive response to dopaminergic treatment. We imaged the striatal dopamine transporter with [(123)I] N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(chloro-phenyl) tropane ([(123)I]IPT) and single-photon emission computed tomography (SPECT) in 28 RLS patients, and compared the results with transporter binding in 29 patients with early PD and 23 age-matched controls. No difference in IPT binding was found between RLS patients and controls. IPT binding was correlated significantly with age in RLS patients and controls, whereas there was no relation with the duration of symptoms or severity of RLS. PD patients presented significant lower presynaptic IPT binding ipsi- and contralateral to the affected body side compared with RLS patients or controls. We found no common characteristics between RLS patients and patients with early PD detectable by dopamine transporter SPECT. Our results do not strengthen an identical pathophysiologic pathway between RLS and PD on the level of nigrostriatal presynaptic terminal function.

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Citations

Jul 25, 2013·Current Neurology and Neuroscience Reports·Giovanni RizzoRaffaele Lodi
Jul 29, 2008·Revue neurologique·E KarroumI Arnulf
May 2, 2007·Sleep Medicine·Thien Thanh Dang-VuPierre Maquet
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May 31, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Alex IranzoWolfgang Oertel
May 29, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Claudia TrenkwalderMarco Zucconi
Jun 21, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Juan C Gómez-EstebanAmaia Ugarte
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Sep 14, 2018·Journal of the Neurological Sciences·Hirotaka IwakiAlberto Ascherio

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