Presynaptic effects of sodium bisulfite at the frog neuromuscular junction

Journal of Neuroscience Research
A Steinacker

Abstract

Both spontaneous and evoked transmitter release from the frog neuromuscular junction can be modified by application of sodium bisulfite, a reagent specific for disulfide bonds. An increase in miniature endplate frequency is produced that is not dependent on external calcium, sodium, or presynaptic terminal depolarization. The increased release can be halted by application of the sulfhydryl oxidizing agent DTNB. The response of bisulfite can be prevented by prior treatment of the endplate with acetylcholine or an anticholinesterase. It is concluded that bisulfite produces its effects by acting on a protein in the presynaptic membrane that is involved in regulation of transmitter release.

Citations

Jun 11, 1998·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·E F Chan, C Mowad

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