PMID: 2507090Sep 25, 1989Paper

Presynaptic inhibition by neuropeptide Y and baclofen in hippocampus: insensitivity to pertussis toxin treatment

Brain Research
W F Colmers, Q J Pittman

Abstract

Neuropeptide Y (NPY) presynaptically inhibits excitatory transmission in area CA1 of rat hippocampus. As postsynaptic NPY receptors in certain other tissues have been shown to be coupled to G-proteins, we have tested the hypothesis that the hippocampal NPY effects are also mediated by G-proteins. Pretreatment of rats with pertussis toxin (PTX) was ineffective in blocking NPY's presynaptic inhibitory actions in area CA1 of the hippocampal slice. The presynaptic inhibitory action of baclofen was also unaffected by PTX pretreatment. However, in these same PTX-pretreated slices, the postsynaptic hyperpolarizing actions of baclofen and 5-hydroxytryptamine were blocked. We suggest that pre- and postsynaptic receptors possess different coupling mechanisms to their effectors.

References

May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D A EwaldR J Miller
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Citations

Feb 1, 1993·Journal of Neuroscience Research·G GimplH Kettenmann
Jan 1, 1995·Pharmacology & Therapeutics·D I Kerr, J Ong
Oct 1, 1991·Trends in Pharmacological Sciences·M C Michel
Jun 1, 1993·Trends in Neurosciences·S M ThompsonM Scanziani
Apr 1, 1994·Progress in Neurobiology·S M Thompson
Nov 6, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Antonio P SilvaEric Grouzmann
Jan 1, 1990·Annals of the New York Academy of Sciences·C WahlestedtD J Reis
Jan 1, 1990·Annals of the New York Academy of Sciences·W F Colmers
May 31, 1993·Annals of the New York Academy of Sciences·S JegouH Vaudry
Apr 1, 1992·Journal of Neurochemistry·I van der PloegB B Fredholm
May 1, 1997·Journal of Cardiovascular Pharmacology·L C RumpP Schollmeyer
Oct 17, 2002·The Journal of Physiology·Jonathon P Wetherington, Nevin A Lambert
Dec 20, 2008·Journal of Neurochemistry·Carolina LaderaJosé Sánchez-Prieto
Feb 7, 1998·Journal of Neurophysiology·M K Tallent, G R Siggins
Feb 5, 2000·Neuropeptides·D R Gehlert

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