Presynaptic inhibition of glutamate transmission by α2 receptors in the VTA.

The European Journal of Neuroscience
C A Jiménez-RiveraF Arencibia-Albite

Abstract

The ventral tegmental area (VTA) forms part of the mesocorticolimbic system and plays a pivotal role in reward and reinforcing actions of drugs of abuse. Glutamate transmission within the VTA controls important aspects of goal-directed behavior and motivation. Noradrenergic receptors also present in the VTA have important functions in the modulation of neuronal activity. Here we studied the effects of α2 noradrenergic receptor activation in the alteration of glutamate neurotransmission in VTA dopaminergic neurons from male Sprague-Dawley rats. We used whole-cell patch-clamp recordings from putative VTA dopaminergic neurons and measured excitatory postsynaptic currents. Clonidine (40 μm) and UK 14,304 (40 μm), both α2 receptor agonists, reduced (approximately 40%) the amplitude of glutamate-induced excitatory postsynaptic currents. After clonidine administration, there was a dose-dependent reduction over the concentration range of 15-40 μm. Using yohimbine (20 μm) and two other α2 adrenergic receptor antagonists, idaxozan (40 μm) and atipemazole (20 μm), we demonstrated that the inhibitory action is specifically mediated by α2 receptors. Moreover, by inhibiting protein kinases with H-7 (75 μm), Rp-adenosine 3',5'-cyclic (11 μm) ...Continue Reading

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Citations

Sep 13, 2016·Frontiers in Synaptic Neuroscience·Marco AtzoriHumberto Salgado
Jun 14, 2013·Journal of Psychopharmacology·Elemer Szabadi
Apr 20, 2019·Journal of Neurochemistry·Michał KielbinskiWojciech B Solecki
May 9, 2014·Journal of Neurophysiology·Jason S Nasse, Joseph B Travers
Nov 2, 2016·The European Journal of Neuroscience·Wendy XinAntonello Bonci
Aug 10, 2020·Neuroscience and Biobehavioral Reviews·Verónica Mäki-MarttunenThomas Espeseth
Mar 7, 2021·International Journal of Molecular Sciences·Yu-Jung ChengHsien-Yuan Lane

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