Presynaptic ionotropic glutamate receptors modulate GABA release in the mouse dorsal motor nucleus of the vagus

Neuroscience
H Xu, Bret N Smith

Abstract

Regulation of GABA release in the dorsal motor nucleus of the vagus (DMV) potently influences vagal output to the viscera. The presence of functional ionotropic glutamate receptors (iGluRs) on GABAergic terminals that rapidly alter GABA release onto DMV motor neurons has been suggested previously, but the receptor subtypes contributing to the response are unknown. We examined the effect of selective activation and inhibition of iGluRs on tetrodotoxin-insensitive, miniature inhibitory postsynaptic currents (mIPSCs) in DMV neurons using patch-clamp recordings in brainstem slices from mice. Capsaicin, which activates transient receptor potential vanilloid type 1 (TRPV1) receptors and increases mIPSC frequency in the DMV via an iGluR-mediated, heterosynaptic mechanism, was also applied to assess GABA release subsequent to capsaicin-stimulated glutamate release. Application of glutamate, N-methyl-d-aspartate (NMDA), or kainic acid (KA), but not AMPA, resulted in increased mIPSC frequency in most neurons. Inhibition of AMPA/KA receptors reduced mIPSC frequency, but selective antagonism of AMPA receptors did not alter GABA release, implicating the presence of presynaptic KA receptors on GABAergic terminals. Whereas NMDA application in...Continue Reading

References

Jan 22, 2004·Nature Reviews. Neuroscience·Holly S Engelman, Amy B MacDermott
Jul 24, 2004·The Journal of Physiology·Andrei V DerbenevBret N Smith
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Young-Ho JinMichael C Andresen
Feb 8, 2006·Annual Review of Physiology·R Alberto TravagliRichard C Rogers
Jul 11, 2006·The Journal of Physiology·Kirsteen N BrowningR Alberto Travagli
Sep 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrei V DerbenevBret N Smith
Jun 2, 2007·The Journal of Physiology·R Alberto Travagli
Aug 24, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kirsteen N Browning, R Alberto Travagli
Dec 19, 2009·Journal of Neurophysiology·Hong Gao, Bret N Smith
Oct 16, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tanja BabicR Alberto Travagli
Dec 15, 2010·Autonomic Neuroscience : Basic & Clinical·Kirsteen N Browning, R Alberto Travagli
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea ZsombokBret N Smith
Dec 3, 2014·Neuroscience Letters·Mariia S Shypshyna, Nikolai S Veselovsky
May 23, 2015·Journal of Neurophysiology·C R BoychukB N Smith

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Citations

Nov 26, 2015·Neuroscience·Guy BouvierPierre Paoletti
Oct 14, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Terry L Powley

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