PMID: 7535906Nov 1, 1994Paper

Presynaptic ionotropic glutamate receptors modulate in vivo release and metabolism of striatal dopamine, noradrenaline, and 5-hydroxytryptamine: involvement of both NMDA and AMPA/kainate subtypes

Neuroscience Research
K OhtaY Fukuuchi

Abstract

In order to explore further the presynaptic modulation of monoamine release by glutamatergic nerve fibers, we investigated the effects of selective agonists for ionotropic glutamate (GLU) receptors on striatal release of dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (5-HT). In the striatum of anesthetized Sprague-Dawley rats, in vivo microdialysis was performed to measure the release of monoamines and metabolities, and also to administer GLU agonists locally in the tissue. L-GLU and its selective agonists (N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) and kainate (KA)) evoked simultaneous release of striatal DA, NA and 5-HT in a dose-dependent manner. Pretreatment with MK-801 (5 mg/kg i.p.), a noncompetitive NMDA receptor antagonist, selectively suppressed NMDA-evoked monoamine release. The rank order of GLU agonist efficacy in releasing monoamines was different among DA, NA, and 5-HTergic terminals: AMPA = KA > NMDA for DA release, AMPA > NMDA = KA for NA release, and NMDA = AMPA = KA for 5-HT release. In conclusion, presynaptic ionotropic GLU receptors exist extensively on monoaminergic terminals including not only catecholaminergic (DA and NA) but also indoleaminerg...Continue Reading

References

Sep 1, 1991·Trends in Pharmacological Sciences·U Trendelenburg
Aug 21, 1990·European Journal of Pharmacology·K FinkM Göthert
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E H WongL L Iversen
Oct 1, 1977·Neuroscience Letters·M F GiorguieffJ Glowinski

❮ Previous
Next ❯

Citations

Dec 17, 1998·Physiology & Behavior·G A Burns, R C Ritter
Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·A PłaźnikM Nazar
Jun 16, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·Y YamamotoK Maeda
Dec 15, 2000·Progress in Neurobiology·T M Tzschentke
Dec 15, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M T AbellánF Artigas
Sep 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura E Halpin, Bryan K Yamamoto
Sep 24, 2004·Journal of Neurochemistry·Yoshinori MasuoEtsuo Niki
Jan 19, 2006·Journal of Neurochemistry·Robert D Staszewski, Bryan K Yamamoto
Jan 10, 2004·Journal of Neurochemistry·Ryuichi FukuiAkinori Nishi
May 6, 2009·Chemico-biological Interactions·Alfonso Alfaro-RodríguezNorma Labra-Ruiz
Oct 22, 2008·The International Journal of Neuroscience·Ilya D Ionov
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M CovasaG A Burns

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.