Presynaptic mGlu7 receptors control GABA release in mouse hippocampus

Neuropharmacology
Maria SummaAnna Pittaluga

Abstract

The functional role of presynaptic release-regulating metabotropic glutamate type 7 (mGlu7) receptors in hippocampal GABAergic terminals was investigated. Mouse hippocampal synaptosomes were preloaded with [(3)H]D-γ-aminobutyric acid ([(3)H]GABA) and then exposed in superfusion to 12 mM KCl. The K(+)-evoked [(3)H]GABA release was inhibited by the mGlu7 allosteric agonist N,N'-dibenzyhydryl-ethane-1,2-diamine dihydrochloride (AMN082, 0.001-10 μM), as well as by the group III mGlu receptor agonist l-(+)-2-amino-4-phosphonobutyric acid [(l)-AP4, 0.01-1 mM]. The mGlu8 receptor agonist (S)-3,4-dicarboxyphenylglycine [(S)-3,4-DCPG, 10-100 nM] was ineffective. AMN082 and (l)-AP4-induced effects were recovered by the mGlu7 negative allosteric modulator (NAM) 6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride (MMPIP). AMN082 also inhibited in a MMPIP-sensitive manner the K(+)-evoked release of endogenous GABA. AMN082 and the adenylyl cyclase (AC) inhibitor MDL-12,330A reduced [(3)H]GABA exocytosis in a 8-Br-cAMP-sensitive. AMN082-inhibitory effect was additive to that caused by (-)baclofen, but insensitive to the GABA(B) antagonist 3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl) pho...Continue Reading

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Citations

Nov 28, 2012·Journal of Neural Transmission·Joanna Wabno, Grzegorz Hess
May 27, 2015·The Journal of Comparative Neurology·Mats Julius StensrudVidar Gundersen
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Nov 9, 2018·Frontiers in Molecular Neuroscience·Nicole M FisherColleen M Niswender
Apr 6, 2020·Genes, Brain, and Behavior·Nicole M FisherColleen M Niswender
Jul 28, 2019·International Journal of Molecular Sciences·Anna Pittaluga
Oct 9, 2018·Frontiers in Molecular Neuroscience·Paulina CieślikJoanna Wierońska
Apr 3, 2019·Chronic Stress·Shigeyuki ChakiKenichi Fukumoto
Dec 11, 2019·The International Journal of Biochemistry & Cell Biology·Ludmila A KasatkinaIrene O Trikash
Jan 10, 2020·Neuroscience·Koyam Morales-WeilMarco Fuenzalida
May 1, 2021·Journal of Clinical Medicine·Waldemar Kryszkowski, Tomasz Boczek

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