Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments

Brain Research Bulletin
A BirthelmerJ-C Cassel

Abstract

Aged (25-27 months) Long-Evans female rats were distinguished according to whether they showed no significant impairment (AU), moderate impairment (AMI), or severe impairment (ASI) in a spatial reference-memory task. Young (3-5 months) rats served as controls. Electrically evoked overflow of tritium was assessed in hippocampal slices preloaded with [3H]choline or [3H]serotonin (5-HT). Nicotine-evoked overflow of tritium was measured after preloading with [3H]noradrenaline (NA). Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activity, and concentration of monoamines were assessed in homogenates. Aged rats exhibited reduced accumulation of [3H]choline and [3H]5-HT, increased accumulation of [3H]NA, and weaker electrically evoked overflow of [3H]acetylcholine ([3H]ACh) and [3H]5-HT. The overflow of [3H]NA was not altered consistently by aging. Roughly, drugs acting presynaptically had comparable effects in aged rats: oxotremorine and CP 93,129 inhibited the overflow of [3H]ACh, CP 93,129 and UK 14,304 reduced that of [3H]5-HT. ChAT or AChE activity, and 5-HT concentration were not changed by age; NA concentration was reduced. When significant, changes were comparable in AU, AMI, and ASI rats. Data show that aging...Continue Reading

References

Jan 1, 1979·Mechanisms of Ageing and Development·C W Cotman, S W Scheff
Jan 1, 1992·The Journal of Pharmacy and Pharmacology·F Huguet, T Tarrade
Feb 1, 1992·Journal of Neuroscience Research·O GhirardiL Angelucci
Jan 1, 1989·Neurobiology of Aging·A L MarkowskaD S Olton
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J SirviöP J Riekkinen
Nov 1, 1989·Neurobiology of Aging·M Gallagher, R D Burwell
Sep 1, 1988·Neurobiology of Aging·M Gallagher, M A Pelleymounter
Nov 1, 1987·Analytical Biochemistry·M B AshourB D Hammock
Feb 1, 1987·Behavioral Neuroscience·P R RappM Gallagher
Dec 1, 1985·Brain Research·S Finger, C R Almli
Jan 1, 1981·Neurobiology of Aging·D K IngramC L Goodrick
Mar 1, 1980·Canadian Journal of Psychology·C A BarnesW K Honig
Dec 17, 1993·Brain Research·J L VeneroJ Cano
May 10, 1995·Annals of the New York Academy of Sciences·H SershenE S Vizi
Jul 1, 1995·Neuroscience·I AubertR Quirion
Mar 1, 1995·Neurobiology of Aging·T D SmithF M Leslie
Nov 1, 1994·Neurobiology of Aging·H TanilaA Honkanen
Apr 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G ZsillaE S Vizi
Oct 17, 1998·Neurobiology of Learning and Memory·P J Colombo, M Gallagher
Mar 20, 1999·Neurobiology of Learning and Memory·B Setlow, J L McGaugh

❮ Previous
Next ❯

Citations

Aug 10, 2010·Chinese Journal of Integrative Medicine·Jia WeiXue-hua Jiang
Nov 26, 2003·Brain Research Bulletin·Theresa SchweizerRolf Jackisch
May 22, 2003·Pharmacology, Biochemistry, and Behavior·A BirthelmerJ-C Cassel
Sep 29, 2005·Behavioral Neuroscience·Véronique PabanBéatrice Alescio-Lautier
Nov 18, 2006·Neurochemical Research·G NiewiadomskaA Mietelska
Dec 10, 2015·Rejuvenation Research·Hao-Bin CaiQi Wang
Jan 18, 2011·Behavioural Brain Research·Magdalini A PapandreouMarigoula Margarity
Feb 13, 2016·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Oron Levin, Yael Netz
Oct 24, 2009·Neuroscience and Biobehavioral Reviews·Rachael D SeidlerDavid B Lipps
Nov 13, 2007·Neurobiology of Aging·Susanne RutzJean-Christophe Cassel
Mar 27, 2007·Neuroscience·S RutzR Jackisch
Jan 15, 2005·Biochemical and Biophysical Research Communications·W Almaguer-MelianJ Bergado
Feb 22, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hong ZhangCheng Peng
Feb 8, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jean-Christophe CasselRolf Jackisch
Jan 30, 2004·Learning & Memory·Patrizio BlandinaMaria Beatrice Passani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.