Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain

Cellular and Molecular Life Sciences : CMLS
Meichun DengHui-Lin Pan

Abstract

Chronic neuropathic pain is a debilitating condition that remains challenging to treat. Glutamate N-methyl-D-aspartate receptor (NMDAR) antagonists have been used to treat neuropathic pain, but the exact sites of their actions have been unclear until recently. Although conventionally postsynaptic, NMDARs are also expressed presynaptically, particularly at the central terminals of primary sensory neurons, in the spinal dorsal horn. However, presynaptic NMDARs in the spinal cord are normally quiescent and are not actively involved in physiological nociceptive transmission. In this review, we describe the emerging role of presynaptic NMDARs at the spinal cord level in chronic neuropathic pain and the implications of molecular mechanisms for more effective treatment. Recent studies indicate that presynaptic NMDAR activity at the spinal cord level is increased in several neuropathic pain conditions but not in chronic inflammatory pain. Increased presynaptic NMDAR activity can potentiate glutamate release from primary afferent terminals to spinal dorsal horn neurons, which is crucial for the synaptic plasticity associated with neuropathic pain caused by traumatic nerve injury and chemotherapy-induced peripheral neuropathy. Furthermor...Continue Reading

References

Mar 24, 1994·Nature·M FarrantS G Cull-Candy
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·H LiuA I Basbaum
Dec 10, 1998·JAMA : the Journal of the American Medical Association·M RowbothamL Magnus-Miller
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·X M Yu, M W Salter
Apr 16, 2002·The Journal of Comparative Neurology·Juan Carlos G MarvizónEmeran A Mayer
Apr 11, 2003·The Journal of Comparative Neurology·Chun-Rong LuJuli G Valtschanoff
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rita BardoniAmy B MacDermott
Sep 16, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Graeme E CorrellRonald E Harbut
Oct 21, 2004·Science's STKE : Signal Transduction Knowledge Environment·Stuart G Cull-Candy, Daniel N Leszkiewicz
Apr 9, 2005·The European Journal of Neuroscience·Masahiro FukayaMasahiko Watanabe
Apr 22, 2005·The Journal of Comparative Neurology·Chun-Rong LuAldo Rustioni
Nov 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jinsong ZengGregory W Terman
Mar 3, 2007·The Journal of Physiology·Sónia F A SantosBoris V Safronov
Feb 13, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ralph-Thomas KieferRobert J Schwartzman
Feb 29, 2008·Journal of Anesthesia·Yukiko NodaShosuke Takahashi
Nov 26, 2008·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Rebekah CorlewBenjamin D Philpot
May 12, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Geraldine A Fuller-BicerArnold Schwartz
Dec 17, 2009·Pain·Amanda R WeyerbacherCharles E Inturrisi
Mar 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hong-Yi ZhouHui-Lin Pan
Aug 19, 2010·Pharmacological Reviews·Stephen F TraynelisRay Dingledine
Feb 8, 2011·Nature Neuroscience·Rylan S LarsenBenjamin D Philpot
Jun 1, 2011·Bone Marrow Transplantation·K KakihanaH Akiyama
Jun 3, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zeng-You YeHui-Lin Pan
Jun 21, 2011·Expert Review of Clinical Pharmacology·Hong-Yi ZhouHui-Lin Pan
Feb 22, 2012·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Antonio Sanz-ClementeKatherine W Roche

❮ Previous
Next ❯

Citations

Jun 17, 2020·Basic & Clinical Pharmacology & Toxicology·Fatemeh AmirkhanlooAhmad Reza Dehpour
Sep 5, 2019·The Journal of Pharmacology and Experimental Therapeutics·Shao-Rui ChenHui-Lin Pan
Aug 11, 2019·Biological Psychiatry·Clifford J Woolf
Jan 7, 2021·International Journal of Molecular Sciences·Antonella Comitato, Rita Bardoni
Feb 13, 2021·Pharmaceuticals·Renata ZajączkowskaJerzy Wordliczek
Nov 4, 2020·The Journal of Physiology·Hovy Ho-Wai WongP Jesper Sjöström
Feb 20, 2021·Biochemistry·Minji JeonAvi Ma'ayan
May 26, 2021·Annals of Clinical and Translational Neurology·Jingchen LiZongmao Zhao
Apr 5, 2021·Diabetes Research and Clinical Practice·Qi ZhangBin Lu
May 27, 2021·Indian Journal of Palliative Care·Gayatri PalatMikael Segerlantz
Aug 24, 2021·Frontiers in Neuroscience·Anton V MalyshevBernhard Luscher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.