PMID: 3756497Aug 27, 1986Paper

Presynaptic suppression of excitatory postsynaptic potentials in rat ventral horn neurons by muscarinic agonists

Brain Research
Z G Jiang, N J Dun

Abstract

In addition to depolarizing the ventral horn cells including antidromically identified motoneurons in thin transverse neonatal rat spinal cord slice preparations, exogenously applied acetylcholine (ACh) suppressed the amplitude of excitatory postsynaptic potentials (EPSPs) either occurring spontaneously or elicited by stimulation of dorsal rootlets. A reduction of EPSPs could still be detected when the ACh-induced depolarization was nullified by hyperpolarizing current. Atropine but not D-tubocurarine effectively antagonized the depolarization and synaptic depression caused by ACh. While depressing the EPSPs, ACh had no appreciable effect on membrane depolarizations elicited by glutamate. Methacholine mimicked the depolarizing and synaptic depressant effects of ACh. The results suggest that muscarinic agonists inhibit synaptic transmission of ventral horn neurons including motoneurons by a presynaptic mechanism in reducing the output of excitatory transmitters.

References

Jan 1, 1978·Annual Review of Pharmacology and Toxicology·G A Johnston
Aug 1, 1981·The Journal of Comparative Neurology·H KimuraE G McGeer

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Citations

May 1, 1989·Neuroscience and Behavioral Physiology·E S Brazhnik, O S Vinogradova
May 5, 2005·Pharmacology, Biochemistry, and Behavior·Lisbeth E GómezRafael Cueva-Rolón
Jun 14, 2008·Journal of Neurophysiology·Katharina A Quinlan, James T Buchanan
Feb 1, 1989·Neuropharmacology·N R Newberry, G P Connolly
Jan 1, 1989·Progress in Neurobiology·R H Evans
Jun 26, 2010·The European Journal of Neuroscience·Didier Le RayRéjean Dubuc
Nov 22, 2014·Frontiers in Neural Circuits·Larry M JordanSerge Rossignol
Mar 27, 2004·Journal of Neurophysiology·Didier Le RayRéjean Dubuc

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