Presynaptic translation: stepping out of the postsynaptic shadow.

Frontiers in Neural Circuits
Michael R AkinsJustin R Fallon

Abstract

The ability of the nervous system to convert transient experiences into long-lasting structural changes at the synapse relies upon protein synthesis. It has become increasingly clear that a critical subset of this synthesis occurs within the synaptic compartment. While this process has been extensively characterized in the postsynaptic compartment, the contribution of local translation to presynaptic function remains largely unexplored. However, recent evidence highlights the potential importance of translation within the presynaptic compartment. Work in cultured neurons has shown that presynaptic translation occurs specifically at synapses undergoing long-term plasticity and may contribute to the maintenance of nascent synapses. Studies from our laboratory have demonstrated that Fragile X proteins, which regulate mRNA localization and translation, are expressed at the presynaptic apparatus. Further, mRNAs encoding presynaptic proteins traffic into axons. Here we discuss recent advances in the study of presynaptic translation as well as the challenges confronting the field. Understanding the regulation of presynaptic function by local protein synthesis promises to shed new light on activity-dependent modification of synaptic ar...Continue Reading

Citations

Dec 19, 2013·Neurochemical Research·Ferzin SethnaHongbing Wang
Aug 12, 2014·Molecular and Cellular Neurosciences·Emily E StackpoleJustin R Fallon
Dec 22, 2012·Neuropharmacology·Lasani S WijetungePeter C Kind
May 11, 2011·Current Opinion in Neurobiology·Aparna Suvrathan, Sumantra Chattarji
Aug 14, 2012·The Journal of Comparative Neurology·Rosa M Giráldez-PérezSalvador Guirado
Dec 24, 2010·Journal of Neurochemistry·Greg T SutherlandJillian J Kril
Jun 1, 2013·Developmental Neurobiology·Denise CookKeith K Murai
Aug 10, 2013·Developmental Neurobiology·Rotem B Perry, Mike Fainzilber
Jun 9, 2015·Frontiers in Cellular Neuroscience·Joseph J BrucknerKate M O'Connor-Giles
May 21, 2011·Trends in Neurosciences·Clarissa L Waites, Craig C Garner
Feb 13, 2016·The Journal of Physiology·Laurent Ferron
Mar 31, 2016·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Aron KosArmaz Aschrafi
Dec 7, 2017·Frontiers in Cellular Neuroscience·James Gilbert, Heng-Ye Man
Jan 5, 2019·Biological Reviews of the Cambridge Philosophical Society·Alessandra DonatoMassimo A Hilliard
Apr 16, 2013·Nature Neuroscience·Jennifer C Darnell, Eric Klann
Dec 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Indulekha P SudhakaranMani Ramaswami
Sep 12, 2019·Frontiers in Synaptic Neuroscience·Sofiia Reshetniak, Silvio O Rizzoli
Jun 5, 2020·Molecular Pain·Xiangyang MeiZhiying Feng
Mar 8, 2019·Nature Communications·Mathias A BöhmeAlexander M Walter
Jan 14, 2017·Human Molecular Genetics·Michael R AkinsJustin R Fallon
Jul 15, 2020·Physical Biology·Saurabh S MogreElena F Koslover
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jieon LeeHyunah Choo
Apr 10, 2013·Molecular Brain·Michael S SidorovMark F Bear
Oct 14, 2021·Cell Reports·Giselle FernandesSumantra Chattarji

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BETA
light microscopy

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