Preterm cord blood CD4⁺ T cells exhibit increased IL-6 production in chorioamnionitis and decreased CD4⁺ T cells in bronchopulmonary dysplasia

Human Immunology
Ravi MisraGloria S Pryhuber

Abstract

Chorioamnionitis (CA) is associated with premature delivery and bronchopulmonary dysplasia (BPD). We hypothesize that preterm infants exposed to CA have reduced suppressive regulatory T cells (Treg) and increased non-regulatory T cell pro-inflammatory cytokines, increasing risk for BPD. To evaluate cord blood CD4(+) T cell regulatory phenotype and pro-inflammatory cytokine production in CA and BPD groups. Cord blood mononuclear cells from infants (GA ⩽32 weeks), with or without placental histological evidence of CA (hChorio), were analyzed by flow cytometry. Clinical information was collected by retrospective chart review. Numbers of putative Treg (CD4(+)FoxP3(+)CD25(+)CD127Dim), CD4(+) non-Tregs, and CD4(+) T cell intracellular cytokine content following in vitro stimulation were compared with CA status and oxygen requirement at 36weeks postmenstrual age. Absolute Treg numbers were not different in CA and non-CA exposed samples. However, the infants who developed BPD had a significant decrease in Treg and non-regulatory T cell numbers. Greater IL-6 production was observed in hCA group. A pro-inflammatory CD4(+) T cell status is noted in CA and BPD but the later disease is also associated with decrease in Tregs, suggesting that...Continue Reading

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References

Sep 1, 1989·Archives of Disease in Childhood·K N ChanM Silverman
Dec 1, 1993·Clinical Obstetrics and Gynecology·E R Newton
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·E BaraldiF Zacchello
Nov 27, 1999·Obstetrics and Gynecology·J C SmulianC V Ananth
May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews
Apr 24, 2001·Current Opinion in Pediatrics·A H Jobe, M Ikegami
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·S H Abman
Feb 28, 2002·The Journal of Pediatrics·Linda J Van MarterUNKNOWN Developmental Epidemiology Network Investigators
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Nov 25, 2003·Current Opinion in Immunology·Omid AkbariDale T Umetsu
Feb 12, 2004·Scandinavian Journal of Immunology·M-F LiuC-R Wu
Feb 20, 2007·American Journal of Obstetrics and Gynecology·Avroy A FanaroffUNKNOWN NICHD Neonatal Research Network
Sep 1, 2007·Clinical Obstetrics and Gynecology·Francesca GotschSonia S Hassan
Apr 4, 2008·The European Respiratory Journal·P M WongD C Chambers
Jun 2, 2009·The Journal of Allergy and Clinical Immunology·Hanna JunttiMatti Uhari
Mar 6, 2010·Immunology·John S YiAllan J Zajac
Jun 24, 2010·Clinics in Perinatology·Alan T N Tita, William W Andrews
Feb 25, 2011·PloS One·Angel A LucianoHelene B Bernstein
May 25, 2011·European Journal of Immunology·Jessica HerrathVivianne Malmström
Jun 24, 2011·Archives of Disease in Childhood. Fetal and Neonatal Edition·Lisa HartlingThierry Lacaze-Masmonteil
May 9, 2012·American Journal of Perinatology·Zubair H AghaiVineet Bhandari
Jul 27, 2012·Trends in Parasitology·Jason P GigleyImtiaz A Khan
Oct 3, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Kristin ScheibleSally Quataert
Jan 16, 2013·Infectious Diseases in Obstetrics and Gynecology·Mara B GreenbergNatali Aziz
Dec 25, 2013·PloS One·Bridgette M DingleDat Q Tran

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Citations

Nov 26, 2015·Clinics in Perinatology·Gloria S Pryhuber
Jul 21, 2016·Journal of Immunological Methods·Ravi S MisraThomas J Mariani
Oct 4, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·David E Surate SolaligueRory E Morty
Aug 29, 2020·International Journal of Molecular Sciences·Shih-Hsin Wang, Po-Nien Tsao
May 6, 2021·Journal of Clinical and Translational Science·Andrew McDavidJeanne Holden-Wiltse
Jun 26, 2021·Frontiers in Pediatrics·Gergely ToldiThillagavathie Pillay
Sep 2, 2021·Clinical & Translational Immunology·Lakshanie C WickramasingheMargaret L Hibbs
Sep 10, 2021·Frontiers in Immunology·Laura S PetersonBrice Gaudilliere
Oct 31, 2021·Journal of Perinatal Medicine·Mandy BusseAna Claudia Zenclussen

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