Preterm Gut Microbiome Depending on Feeding Type: Significance of Donor Human Milk

Frontiers in Microbiology
Anna Parra-LlorcaM Carmen Collado

Abstract

Preterm microbial colonization is affected by gestational age, antibiotic treatment, type of birth, but also by type of feeding. Breast milk has been acknowledged as the gold standard for human nutrition. In preterm infants breast milk has been associated with improved growth and cognitive development and a reduced risk of necrotizing enterocolitis and late onset sepsis. In the absence of their mother's own milk (MOM), pasteurized donor human milk (DHM) could be the best available alternative due to its similarity to the former. However, little is known about the effect of DHM upon preterm microbiota and potential biological implications. Our objective was to determine the impact of DHM upon preterm gut microbiota admitted in a referral neonatal intensive care unit (NICU). A prospective observational cohort study in NICU of 69 neonates <32 weeks of gestation and with a birth weight ≤1,500 g was conducted. Neonates were classified in three groups according to feeding practices consisting in their MOM, DHM, or formula. Fecal samples were collected when full enteral feeding (defined as ≥150 cc/kg/day) was achieved. Gut microbiota composition was analyzed by 16S rRNA gene sequencing. Despite the higher variability, no differences i...Continue Reading

Associated Clinical Trials

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Datasets Mentioned

BETA
PRJEB25948

Methods Mentioned

BETA
PCR
cesarean section

Software Mentioned

PICRUSt
Calypso
PICRUSt ( Phylogenetic Investigation of Communities by Reconst...
PERMANOVA
R Core Team
QIIME
RStatistics

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