Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative Stress

Journal of Immunology Research
Clarissa Gutierrez CarvalhoRita de Cassia Silveira

Abstract

Ventilator-induced lung injury is well recognized, and appropriate arterial saturation target is unknown, so gentle modes of ventilation and minimizing oxidative stress have been well studied. Our objective was to analyze any association between the oxygen levels at blood sampling and plasma levels of the interleukins IL-6, IL-1β, IL-10, and IL-8 and TNF-α in preterm newborns under mechanical ventilation (MV) in their first two days. Methods. Prospective cohort including neonates with severe respiratory distress. Blood samples were collected right before and 2 hours after invasive MV. For analysis purposes, newborns were separated according to oxygen requirement: low oxygen (≤30%) and high oxygen (>30%) groups. Interleukins were measured using a commercially available kit. Results. 20 neonates (gestational age 32.2 ± 3 weeks) were evaluated. Median O2 saturation levels pre-MV were not different in both oxygen groups. In the high oxygen group, IL-6, IL-8, and TNF-α plasma levels increased significantly after two hours under MV. Conclusions. Despite the small sample studied, data showed that there is a relationship between VILI, proinflammatory cytokines, and oxygen-induced lung injury, but a study considering oxidative marker me...Continue Reading

References

Jan 8, 2008·Lancet·Robert L GoldenbergRoberto Romero
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Vineet Bhandari
Sep 29, 2009·The Journal of Pediatrics·Betania BohrerRenato S Procianoy
May 8, 2014·Oxidative Medicine and Cellular Longevity·Chiara Poggi, Carlo Dani
Jan 17, 2015·Canadian Journal of Physiology and Pharmacology·Elizabeth R VogelY S Prakash

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Citations

Feb 13, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Xin Lin, Changyi Yang

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Methods Mentioned

BETA
bronchoalveolar

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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