Preterm premature rupture of membranes at 22-25 weeks' gestation: perinatal and 2-year outcomes within a national population-based study (EPIPAGE-2)

American Journal of Obstetrics and Gynecology
Elsa LortheGilles Kayem

Abstract

Most clinical guidelines state that with early preterm premature rupture of membranes, obstetric and pediatric teams must share a realistic and individualized appraisal of neonatal outcomes with parents and consider their wishes for all decisions. However, we currently lack reliable and relevant data, according to gestational age at rupture of membranes, to adequately counsel parents during pregnancy and to reflect on our policies of care at these extreme gestational ages. We sought to describe both perinatal and 2-year outcomes of preterm infants born after preterm premature rupture of membranes at 22-25 weeks' gestation. EPIPAGE-2 is a French national prospective population-based cohort of preterm infants born in 546 maternity units in 2011. Inclusion criteria in this analysis were women diagnosed with preterm premature rupture of membranes at 22-25 weeks' gestation and singleton or twin gestations with fetus(es) alive at rupture of membranes. Latency duration, antenatal management, and outcomes (survival at discharge, survival at discharge without severe morbidity, and survival at 2 years' corrected age without cerebral palsy) were described and compared by gestational age at preterm premature rupture of membranes. Among the...Continue Reading

Citations

Jan 5, 2019·Current Opinion in Pediatrics·Bonnie H Arzuaga, Christy L Cummings
Oct 28, 2019·The Journal of Obstetrics and Gynaecology Research·Takeshi OnoMasatoshi Yokoyama
Feb 23, 2020·Journal of Perinatal Medicine·Jose GalazNardhy Gomez-Lopez
Jun 17, 2020·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·Michal ZajicekShlomo Lipitz
Nov 25, 2019·Archives of Gynecology and Obstetrics·M GuckertC Garabedian
Dec 12, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·George N GwakoFredrick Were
Dec 22, 2020·Frontiers in Pediatrics·Paola LagoFranca Benini
Jun 25, 2021·International Journal of Epidemiology·Elsa LortheUNKNOWN EPIPAGE-2 Study group
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Nov 6, 2021·American Journal of Obstetrics and Gynecology·Ariel SklarStephanie B Teal

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