Preterm umbilical cord blood derived mesenchymal stem/stromal cells protect preterm white matter brain development against hypoxia-ischemia

Experimental Neurology
Jingang LiSuzanne L Miller

Abstract

Preterm infants are at high risk for white matter injury and subsequent neurodevelopmental impairments. Mesenchymal stem/stromal cells (MSC) have anti-inflammatory/immunomodulatory actions and are of interest for neural repair in adults and newborns. This study examined the neuroprotective effects of allogeneic MSC, derived from preterm umbilical cord blood (UCB), in a preterm sheep model of white matter injury. Quad-lineage differentiation, clonogenicity and self-renewal ability of UCB-derived MSC were confirmed. Chronically instrumented fetal sheep (0.7 gestation) received either 25 min hypoxia-ischemia (HI) to induce preterm brain injury, or sham-HI. Ten million MSC, or saline, were administered iv to fetuses at 12 h after HI. Fetal brains were collected 10d after HI for histopathology and immunocytochemistry. HI induced white matter injury, as indicated by a reduction in CNPase-positive myelin fiber density. HI also induced microglial activation (Iba-1) in the periventricular white matter and internal capsule (P < .05 vs control). MSC administration following HI preserved myelination (P < .05), modified microglial activation, and promoted macrophage migration (CD163) and cell proliferation (Ki-67) within cerebral white matt...Continue Reading

Citations

May 19, 2019·International Journal of Molecular Sciences·Dariusz BoruczkowskiIzabela Zdolińska-Malinowska
Aug 11, 2019·Molecular Neurobiology·María F Zappa VillarPaula C Reggiani
Dec 5, 2019·Journal of Neuroscience Research·Xirui PengXiaoyang Wang
Mar 3, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Kenta Ht ChoAlistair J Gunn
Apr 8, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Elizabeth K BakerPeter G Davis
Aug 14, 2020·Cells·Daan R M G OpheldersTim G A M Wolfs
Mar 21, 2020·Frontiers in Endocrinology·Beth J AllisonSuzanne L Miller
May 22, 2019·International Journal of Molecular Sciences·Courtney A McDonaldSuzanne L Miller
Nov 17, 2020·Frontiers in Neurology·Emily Ross-MunroDavid W Walker
Feb 11, 2021·International Journal of Molecular Sciences·Nathanael YatesJoanne O Davidson
Apr 2, 2020·Current Stem Cell Research & Therapy·Xiaojie BaiHong Zhang

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