Pretibial pruritic papular dermatitis: A distinctive cutaneous manifestation in response to chronic rubbing

The American Journal of Dermatopathology
Giorgio AnnessiAngela Petresca

Abstract

We describe the clinico-pathologic features of 44 patients with a peculiar pretibial pruritic papular dermatitis (PPPD). Clinically, PPPD consists of discrete, roundish, extremely pruritic papules with a smooth surface caused by the delicate and persistent rubbing of pretibial skin. Histologically, PPPD showed minimal compact orthokeratosis, flattening of the rete ridges, a superficial and mid-dermal perivascular and interstitial infiltrate of lymphocytes, histiocytes, eosinophils and multinucleated fibroblasts, and thickened collagen bundles in haphazard array in the superficial dermis. The clinical picture of PPPD closely resembled that of lichen simplex chronicus/circumscribed neurodermatitis or lichen amyloidosus. Histologically, the absence of uneven psoriasiform epidermal hyperplasia, marked compact orthokeratosis, hypergranulosis, and coarse bundles of collagen arranged in vertical streaks in the papillary dermis distinguished PPPD from lichen simplex chronicus, whereas the lack of amyloid deposits in the dermal papillae differentiated PPPD from lichen amyloidosus. We suggest that PPPD is an unusual morphologic expression of gentle and chronic rubbing of pretibial skin with distinctive histopathologic features.

References

Oct 1, 1979·Journal of Cutaneous Pathology·J A DoyleR K Winkelmann
Apr 1, 1975·The British Journal of Dermatology·I M RoberstonF A Whitlock
Nov 1, 1975·Archives of Dermatology·E J Feuerman, M Sandbank
Sep 1, 1990·International Journal of Dermatology·J U Yi, C W Lee
Jan 1, 1990·Dermatologica·M AelbrechtJ De Bersaques
Jan 1, 1988·Journal of the American Academy of Dermatology·S M Breathnach
Oct 1, 1985·The British Journal of Dermatology·C M Rowland PayneM M Black
Jun 1, 1973·The British Journal of Dermatology·S S Bleehen, I R Edwards
Sep 1, 1974·Archives of Dermatology·L RoeJ W Wilson
Mar 1, 1973·The British Journal of Dermatology·R Marks, G C Wells
Dec 1, 1973·The British Journal of Dermatology·G Singh
Feb 1, 1970·The British Journal of Dermatology·C H Tay, J L Dacosta
Nov 1, 1965·Archives of Dermatology·J W MaliA A Hamers
Mar 1, 1994·International Journal of Dermatology·B RaoE Poulos
Jan 1, 1995·Dermatology : International Journal for Clinical and Investigative Dermatology·M TanakaH Tagami
Apr 1, 1997·Nature Biotechnology·A Marshall, A Castellino
Jan 7, 1998·Journal of the American Academy of Dermatology·W WeyersW B Schill
Sep 6, 2000·Journal of the European Academy of Dermatology and Venereology : JEADV·L W Accioly-FilhoM Ramos-e-Silva
Apr 1, 1964·Archives of Dermatology·M A COWAN
May 1, 1964·Archives of Dermatology·M A COWAN

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Citations

Apr 7, 2007·The American Journal of Dermatopathology·Greg WolgamotZsolt Argenyi
Aug 11, 2010·The Australasian Journal of Dermatology·Rowland Noakes, Nicholas Mellick
Jun 13, 2019·The American Journal of Dermatopathology·Shadai FloresAnneli R Bowen
Jun 22, 2017·The Australasian Journal of Dermatology·Enzo Errichetti, Giuseppe Stinco

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