Pretransplant calcium levels have no predictive value for delayed graft function, long-term graft function, cardiovascular events, or graft and patient survival in renal transplantation

Transplantation Proceedings
Bernd KrügerBernhard K Krämer

Abstract

Disorders of calcium homeostasis are one of the most common problems in patients with end-stage renal disease (ESRD). Elevated calcium levels increase the incidence of cardiovascular mortality in ESRD patients, and appear to be a risk factor for the occurrence of delayed graft function (DGF) after kidney transplantation. Therefore, we investigated the impact of pretransplant serum calcium levels on outcomes after kidney transplantation: DGF, acute rejection, graft function, and survival, as well as the incidence of cardiovascular events. We studied 285 patients (96.9% of all transplanted patients) who underwent their first transplantation between 1995 and 2004. Demographic data were extracted from hospital records or were documented during follow-up; serum samples were collected at the time of transplantation. In our cohort the incidence of DGF was 16.5% and 35.4% of acute rejection episodes (ARE). However, pretransplant calcium levels were not related to DGF or ARE in our patient cohort. Furthermore, there was no correlation between pretransplant serum calcium level with the incidence of cardiovascular events or mortality, as well as graft function or survival. In our study population pretransplant calcium levels showed no eff...Continue Reading

References

Jan 1, 1996·American Journal of Nephrology·R N FoleyP E Barre
Mar 26, 2002·JAMA : the Journal of the American Medical Association·Preston S KlassenWilliam F Owen
Apr 13, 2004·Transplantation·Henk BoomLeendert A van Es
Apr 9, 2005·Journal of the American Society of Nephrology : JASN·Yelena SlininAllan J Collins
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Wilfried GwinnerAnke Schwarz

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Citations

Apr 15, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sri G YarlagaddaChirag R Parikh
May 15, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Bernd KrügerBernhard K Krämer
Feb 13, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Bernd KrügerBernhard K Krämer
May 10, 2007·Clinical Transplantation·Bernd KrügerBernhard K Krämer
Sep 8, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Miklos Z MolnarKamyar Kalantar-Zadeh

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