Pretransplant screening and evaluation of liver graft viability using machine perfusion preservation in porcine transplantation

Transplantation Proceedings
H ObaraH Mizunuma

Abstract

A novel method using machine perfusion for pretransplant screening and evaluation of the viability of liver grafts has been proposed, seeking to prevent severe ischemia-reperfusion injury and to reduce the risk of primary graft nonfunction. This study sought to evaluate the viability of critical grafts, which were obtained from expanded criteria donors or donation after cardiac death donors during preservation with a new machine preservation perfusion system (NES-01). The normalized pressure transition in the hepatic artery was employed as an evaluation index for liver viability. As a result, the normalized pressure (p/p(0)) in the hepatic artery showed a distinctive transition under each experimental conditions controlled by warm ischemic time (WIT). The high viability graft, obtained under the condition of WIT as 0 minutes (WIT0), showed a quick response to hepatic artery pressure after initiating perfusion, whereas the normalized pressure showed a sudden decrease. In contrast, the normalized pressure among WIT60, which may cause the graft to lose viability, showed a poor hepatic artery response. These findings corresponded to the cumulative release of enzymes. The findings of our study suggest that monitoring of the pressure...Continue Reading

References

Feb 28, 2002·Lancet·Shawn D St PeterPeter J Friend
Apr 18, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P DutkowskiP-A Clavien
Jan 2, 2009·The New England Journal of Medicine·Cyril MoersRutger J Ploeg
Dec 5, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J V GuarreraJ C Emond
Dec 17, 2010·Annals of Biomedical Engineering·B M DoorschodtR H Tolba
May 14, 2011·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Edgardo E GuibertBarry J Fuller

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Citations

Nov 29, 2013·Transplantation Research·Naoto Matsuno, Eiji Kobayashi
Apr 23, 2014·Nature Reviews. Gastroenterology & Hepatology·Maxim NebrigAndreas Pascher
May 13, 2014·Transplantation Proceedings·N MatsunoH Furukawa
Apr 2, 2014·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Xiao-Bo Chen, Ming-Qing Xu
Jun 19, 2013·Transplantation Proceedings·H ObaraH Mizunuma
May 7, 2014·Journal of Hepatology·Cornelia J VerhoevenLuc J W van der Laan
Apr 3, 2015·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Toshitaka YasudaShin Enosawa
May 1, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S A KarangwaR J Porte
Feb 28, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hazel MareckiPaulo N Martins
May 24, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Cristiano QuintiniUNKNOWN American Society of Transplant Surgeons Standards Committee
Aug 22, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Zoltan CziganyGeorg Lurje
Jun 2, 2020·Frontiers in Immunology·Thomas ReschSefan Schneeberger
Dec 27, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R Cutler Quillin, James V Guarrera

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