Pretransplantation Minimal Residual Disease Predicts Survival in Patients with Mantle Cell Lymphoma Undergoing Autologous Stem Cell Transplantation in Complete Remission

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Andrew J CowanA K Gopal

Abstract

Autologous stem cell transplantation (ASCT) is standard therapy for mantle cell lymphoma (MCL) in remission after induction chemotherapy, with the best results for patients in complete remission (CR). We hypothesized that evaluation of minimal residual disease (MRD) before ASCT could further stratify outcomes for these patients. Patients with MCL who underwent ASCT in clinical CR between 1996 and 2011 with pretransplantation MRD testing were eligible. Presence of a clonal IgH rearrangement, t(11; 14) by PCR or positive flow cytometry from blood or bone marrow, was considered positive. An adjusted proportional hazards model for associations with progression-free (PFS) and overall survival (OS) was performed. Of 75 MCL patients in CR, 8 (11%) were MRD positive. MRD positivity was associated with shorter OS and PFS. The median OS for MRD-negative patients was not reached, with 82% survival at 5 years, whereas for the MRD-positive patients, median OS was 3.01 years (hazard ratio [HR], 4.04; P = .009), with a median follow-up of 5.1 years. The median PFS for MRD-negative patients was not reached with 75% PFS at 5 years, whereas for MRD-positive patients, it was 2.38 years (HR, 3.69; P = .002). MRD positivity is independently associa...Continue Reading

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Citations

May 2, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Timothy S FenskeChristopher Bredeson
Sep 30, 2016·Leukemia & Lymphoma·Elisabet E Manasanch
Oct 21, 2016·Cell Biology and Toxicology·Michael P ChuLinda M Pilarski
Jun 27, 2017·Cancer Treatment Reviews·Peter MartinMartin Dreyling
Sep 22, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alex F Herrera, Philippe Armand
Aug 12, 2017·Leukemia & Lymphoma·Daniel M GuidotJonathon B Cohen
Feb 28, 2019·Current Hematologic Malignancy Reports·Jennifer Crombie, Philippe Armand
Mar 8, 2019·Expert Review of Hematology·I Brian Greenwell, Jonathon B Cohen
Aug 24, 2017·Current Opinion in Hematology·Umberto Falcone, John Kuruvilla
Oct 28, 2017·British Journal of Haematology·Matthew L Chase, Philippe Armand
Jul 15, 2018·Journal of Experimental & Clinical Cancer Research : CR·Haige YeMichael L Wang
Sep 26, 2020·Journal of Hematology & Oncology·Dayoung JungMichael Wang
Aug 31, 2020·Hematology/oncology Clinics of North America·Thomas D Rodgers, Jonathan W Friedberg
Mar 31, 2021·British Journal of Haematology·Elisabeth SilkenstedtMartin Dreyling
May 10, 2021·Transplantation and Cellular Therapy·Farah YassineMohamed A Kharfan-Dabaja

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