PMID: 3745966May 1, 1986Paper

Pretreatment effects on the uptake/retention kinetics of L-dopa in Harding-Passey melanoma

The Journal of Investigative Dermatology
R A BerjianD D Lawrence

Abstract

Malignant melanoma cells possess a unique biochemical pathway that converts L-3,4-dihydroxyphenylalanine (L-dopa) to the biopigment melanin. Selective cytotoxic incorporation of exogenous L-dopa into melanoma cells in vivo may provide a means of designing specific chemotherapeutic agents useful in the treatment of this disease. Using the Harding-Passey murine melanotic tumor model, a preferential uptake of [3H]L-dopa by the tumor was characterized. Following pretreatment of the tumor-bearing mice with nonradioactive L-dopa, a significant enhancement (p less than 0.01) of [3H]L-dopa incorporation and retention into melanoma for a period of 24 h was observed, when compared with the concomitant tissue distribution and clearance of radioactivity in the control animals. This finding suggests that by initial pretreatment of melanoma with nonradioactive L-dopa, the subsequent selective accumulation of [3H]L-dopa in tumor may provide a useful tool in testing new modalities of therapy in malignant melanoma.

References

Apr 1, 1976·The Journal of Investigative Dermatology·J M Pawelek
Jun 1, 1978·The Journal of Investigative Dermatology·M M WickM Gorman
Jul 29, 1977·Science·M M WickE Frei
Jun 1, 1983·The Journal of Investigative Dermatology·M M Wick

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Citations

Apr 1, 1987·The Journal of Dermatologic Surgery and Oncology·A W KopfS L Gumport
Mar 8, 1990·Journal of Theoretical Biology·A Slominski, R Paus

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