Pretreatment hematologic markers as prognostic predictors of gastroenteropancreatic neuroendocrine tumors: a systematic review and meta-analysis

OncoTargets and Therapy
Yu ZhouBaohua Hou

Abstract

Systemic inflammation can be reflected by peripheral hematologic parameters and combined index like the lymphocyte count, neutrophil count, platelet count, neutrophil-to-lymphocyte (NLR), and platelet-to-lymphocyte ratio (PLR). This systematic review and meta-analysis aimed to summarize the association between the hematologic markers and prognosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). A computerized systematic search of PubMed, Embase, and Web of Science was conducted up to August 2016. Studies evaluating prognosis value of hematologic parameters in patients with GEP-NETs were retrieved. For meta-analysis, hazard ratios (HRs) with 95% confidence intervals (95% CIs) were extracted and synthesized using Review Manager software. We identified eight retrospective cohort studies comprising a total of 724 cases. The majority of included studies focused on pancreatic neuroendocrine tumors (PNETs). The prognostic values of NLR, PLR, and platelet count were reported in six studies, two studies, and one study, respectively. All the parameters were associated with prognostic outcomes in patients with GEP-NETs. A high NLR was significantly associated with poor prognosis in GEP-NETs (pooled HR 3.05, 95% CI 1.96-4.76, I...Continue Reading

Citations

Jan 25, 2020·Anti-cancer Drugs·Tal GrenaderUNKNOWN CLARINET Study Group
Jun 30, 2021·Cancer Biotherapy & Radiopharmaceuticals·Swayamjeet SatapathyBhagwant Rai Mittal
Apr 11, 2021·The Journal of Clinical Endocrinology and Metabolism·Pedro MarquesAlberto M Pereira

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