Pretreatment macrophage infiltration of the synovium predicts the clinical effect of both radiation synovectomy and intra-articular glucocorticoids.

Annals of the Rheumatic Diseases
Z N JahangierP P Tak

Abstract

To explore whether pretreatment features of synovial tissue in patients with gonarthritis could predict the clinical effect of radiation synovectomy with yttrium-90 (90Y) and glucocorticoids or with intra-articular glucocorticoids alone. A synovial biopsy was carried out blindly 2 weeks before treatment in 66 patients with persistent gonarthritis, who were randomised to treatment either with 90Y and triamcinolone or with placebo and triamcinolone. Immunohistochemistry was used to detect T cells, macrophages, B cells, plasma cells, fibroblast-like synoviocytes, adhesion molecules and pro-inflammatory cytokines. Stained sections were evaluated by digital image analysis. Individual patient improvement was expressed using a composite change index (CCI; range 0-12). Successful treatment was defined as CCI > or = 6 after 6 months. Patients with rheumatoid arthritis, psoriatic arthritis, undifferentiated arthritis and other causes of gonarthritis were included. The overall response rate was 47%. Clinical efficacy in both therapeutic groups was similar and not dependent on diagnosis. No significant differences were noted between baseline microscopic features of synovial tissue inflammation in patients with rheumatoid arthritis and in t...Continue Reading

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Citations

Apr 7, 2007·Current Opinion in Rheumatology·Zoltán Szekanecz, Alisa E Koch
Jun 6, 2008·Current Opinion in Rheumatology·David L Boyle, Arthur Kavanaugh
Dec 23, 2006·Annals of the Rheumatic Diseases·Joel A G van RoonFloris P J G Lafeber
Jun 4, 2013·Vascular Cell·Nicola MaruottiDomenico Ribatti
Oct 11, 2013·Future Oncology·Floortje G M VerspoorH W Bart Schreuder
May 1, 2009·Arthritis and Rheumatism·John A Hamilton, Paul P Tak
Jun 9, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Eric L StaalsEmanuela Palmerini
Apr 17, 2020·Expert Review of Anticancer Therapy·Emanuela PalmeriniEric Lodewijk Staals
Nov 18, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·A OgdieFrank Pessler
Oct 4, 2018·Drug Delivery and Translational Research·Durga M S H ChandrupatlaGerrit Jansen
May 28, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Margit SzentesiWillm Uwe Kampen
May 6, 2020·International Journal of Molecular Sciences·Maqsood YaqubConny J van der Laken
Jan 22, 2021·Autoimmunity Reviews·Jeffrey M A van der KrogtSander W Tas

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