Pretreatment neutrophil-lymphocyte and platelet-lymphocyte ratio predict clinical outcome and prognosis for cervical Cancer

Clinica Chimica Acta; International Journal of Clinical Chemistry
MeiLin ZhuLuShun Zhang

Abstract

Variations in systemic inflammatory response biomarker levels have been associated with adverse clinical outcome in various malignancies. In this study, we aimed to evaluate the predictive and prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in cervical cancer. We retrospectively investigated 616 patients who underwent initial radical hysterectomy with pelvic lymphadenectomy for cervical cancer between July 2012 and December 2014 in China. Their clinical and histopathological markers and complete blood counts were obtained and analyzed. Then we chose the group of 339 of the total 616 patients who were not combined preoperative radiotherapy or chemotherapy for the survival analysis. Prognostic factors were assessed by univariate and multivariate analyses. The ROC curve revealed NLR and PLR had significant ability to predict parametrial involvement, and the cutoff values for NLR and PLR were 2.5 and 138.8 respectively. Clinicopathologic analysis showed that NLR was linked to age, parametrial involvement, tumor-invasion depth and histologic grade, and PLR was related to age, parametrial involvement, tumor-invasion depth and FIGO stage. Univariate analysis identified hi...Continue Reading

Citations

Apr 11, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Murat MuratogluMehmet Haberal
May 29, 2020·Biomarkers in Medicine·Tanya N Augustine
Oct 14, 2018·World Journal of Surgical Oncology·Li ZhuDihong Tang
Jul 20, 2021·Cancer Management and Research·Michal MlekoTomasz Banas
Aug 6, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Luiz Claudio Santos ThulerAnke Bergmann

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