Abstract
The neutrophil-to-lymphocyte ratio (NLR) has been shown to be associated with prognosis in various types of cancer. We evaluated pretreatment NLR as a predictor of poor prognosis in patients with hepatocellular carcinoma (HCC), and we compared the prognostic value of NLR with other prognostic scores.We retrospectively analyzed 825 patients diagnosed with HCC between October 2008 and May 2012. Baseline data, including the NLR and the Child-Pugh class or Model for End-Stage Liver Disease (MELD) score, were recorded before treatment. The relationships between overall survival (OS) and the study variables were assessed using univariate and multivariate analyses and receiver operating characteristic (ROC) curves. The prognostic value of NLR was assessed using a Kaplan-Meier survival analysis and compared with that of the Barcelona-Clinic Liver Cancer (BCLC) and Tumor, Node, Metastasis (TNM) staging.The NLR, γ-glutamyltranspeptidase, α-fetoprotein ≥ 400 ng/mL, tumor number ≥ 3, tumor size ≥ 5 cm, lymph node metastasis, portal vein involvement, and Child-Pugh class were significantly associated with OS. The NLR demonstrated the strongest prognostic value (area under ROC curve = 0.811). An NLR ≥ 2.7 was a significant predictor of poor ...Continue Reading
References
Jun 23, 2001·Annals of Surgery·R T PoonJ Wong
Mar 8, 2002·Annals of Surgery·Ronnie Tung-Ping PoonJohn Wong
Nov 15, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·V ZiparoE Fernandes
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
May 29, 2004·Angiogenesis·Yoka H KusumantoNanno H Mulder
Mar 28, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Calogero Cammà, Giuseppe Cabibbo
May 12, 2009·International Journal of Cancer. Journal International Du Cancer·Braedon McDonaldLorenzo E Ferri
Jan 8, 2010·World Journal of Surgical Oncology·Farhan RashidSyed Y Iftikhar
Feb 4, 2010·American Journal of Surgery·Imran BhattiRichard I Hall
Feb 23, 2010·Seminars in Liver Disease·Alejandro FornerJordi Bruix
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Mar 26, 2011·Science·Robert D SchreiberMark J Smyth
May 7, 2011·Annals of Surgical Oncology·Reem Z SharaihaJulian A Abrams
Aug 10, 2011·The Journal of Pathology·Yan WuDong-Ming Kuang
Sep 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroshi KonoMichio Hara
Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag
May 29, 2012·Journal of Hepatology·Kai FengJiahong Dong
Aug 11, 2012·British Journal of Cancer·A KinoshitaH Tajiri
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 22, 2013·PloS One·Jiaqiang DanMinshan Chen
Jun 19, 2013·Annals of Surgery·Yohei ManoYoshihiko Maehara
Oct 15, 2013·Journal of Surgical Oncology·Kevin M SullivanT Clark Gamblin
Mar 13, 2014·PloS One·Jin-feng ZhangChang-quan Ling
Citations
Feb 13, 2016·Medicine·Yan FuQuan Zhang
Feb 26, 2016·BMC Cancer·Fei JiYun-Peng Hua
Dec 25, 2015·Trends in Immunology·Davalyn R Powell, Anna Huttenlocher
Oct 2, 2015·Medicine·Jun-Te HsuTa-Sen Yeh
Jun 17, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y ZhangX Qu
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Richard E KastMarc-Eric Halatsch
Feb 24, 2017·PloS One·Xiaoli LiuZhiyun Yang
Sep 21, 2017·Shock·Nicolas MoreauDiego Castanares-Zapatero
Feb 18, 2018·British Journal of Biomedical Science·N MousaW Eldars
Mar 13, 2018·Shock·Weijing LiZongan Liang
Mar 1, 2019·Medicine·Zuojian HuShan Li
Jul 12, 2017·Journal of Pediatric Hematology/oncology·Liliana VasquezJenny Geronimo
Oct 27, 2015·Medicine·Matteo FerroDaniela Terracciano
Dec 3, 2016·Oncotarget·Kyoung-Min ChoYung-Jue Bang
Dec 31, 2015·Oncotarget·Gui-Qian HuangMeng-Tao Zhou
Jun 16, 2016·Oncotarget·Xingshun QiXiaozhong Guo
Dec 22, 2017·Oncotarget·Alberto LuéBruno Sangro
Jul 30, 2016·Oncotarget·Fei JiBaogang Peng
Nov 8, 2017·Clinical Transplantation·Guang-Tao MinWei Chen
Jun 28, 2019·International Journal of Clinical Oncology·Shiqi ChenChunmeng Wang
Apr 24, 2020·BMC Gastroenterology·Wei-Long ChangPeng Zhang
Jan 1, 2017·Acta Biochimica Et Biophysica Sinica·Anwei XueYingyong Hou
Feb 2, 2017·BMC Cancer·Gang WanXianbo Wang
Apr 23, 2017·Annals of Surgical Oncology·Wu-Chia LoYih-Leong Chang
Sep 22, 2020·World Journal of Gastroenterology : WJG·Ayman Bannaga, Ramesh P Arasaradnam
Jan 14, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Xi LiBeau Toskich
Nov 18, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Qinqin LiuLu Zheng
Jul 15, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Kyohei YugawaHiroyuki Matsuda