PMID: 2103309Jan 1, 1990Paper

Pretreatment of human vascular smooth muscle cells with interleukin-1 enhances interleukin-6 production and cell proliferation (action of IL-1 on vascular smooth muscle cells)

Autoimmunity
K NoriokaH Nakamura

Abstract

Systemic vasculitis is an inflammatory disorder of blood vessels characterized by a perivascular mononuclear cell infiltration around the vessel and fibrinoid necrosis within vessel walls. Interleukin-1 (IL-1) is a multipotent inflammatory mediator and affects several properties of vascular cells. To determine whether IL-1 could contribute to the pathogenesis of vascular diseases, we examined the effect of IL-1 on B cell stimulatory factor-2/interleukin-6 (IL-6) production by cultured human vascular smooth muscle cells (SMC) and the proliferation of these cells. Supernatants of SMC stimulated IgM synthesis of human B cell line. SKW6-CL4 cells. This activity was increased (1.7 to 2.6-fold) when SMC were pretreated with IL-1 or calcium ionophore A23187 for 48 h, and was completely blocked by rabbit anti-human IL-6 antibodies. These IL-6 activities of the SMC supernatants were also assessed by using an IL-6 dependent murine hybridoma cell line. MH-60. BSF-2. In addition, we observed that pretreatment of SMC with IL-1 for 48 h stimulated growth of SMC during the 96 h incubations, as assessed by cell number (p less than 0.05). These results suggest that IL-1 may contribute to the pathogenesis of inflammatory and immunological vascul...Continue Reading

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Citations

Oct 11, 2005·Brain, Behavior, and Immunity·Lena BrydonAndrew Steptoe
Nov 13, 1996·Journal of Immunological Methods·A I Dongari-Bagtzoglou, J L Ebersole
Jun 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·K Takahasi, Y Sawasaki
Feb 1, 1993·Journal of Cardiothoracic and Vascular Anesthesia·T SakaiD N O'Flaherty
Jan 15, 2013·The American Journal of Pathology·Jean-Philippe GiotLaure Favot
Dec 1, 2017·International Journal of Molecular Sciences·Sean P Didion
Jan 5, 1999·The Journal of Experimental Medicine·N KiuchiT Hirano
Mar 5, 2003·Pharmacological Reviews·Jan H von der ThüsenErik A L Biessen
Feb 16, 2007·Pediatric Transplantation·Hao MaJieshou Li
Aug 21, 2003·Journal of Biomedical Science·Gursev S DhaunsiRonald B Turner

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