Pretreatment of periosteum with TGF-beta1 in situ enhances the quality of osteochondral tissue regenerated from transplanted periosteal grafts in adult rabbits.

Osteoarthritis and Cartilage
A Olivos-MezaG G Reinholz

Abstract

To compare the efficacy of in situ transforming growth factor-beta1 (TGF-beta1)-pretreated periosteum to untreated periosteum for regeneration of osteochondral tissue in rabbits. In the pretreatment group, 12 month-old New Zealand white rabbits received subperiosteal injections of 200 ng of TGF-beta1 percutaneously in the medial side of the proximal tibia, 7 days prior to surgery. Control rabbits received no treatment prior surgery. Osteochondral transverse defects measuring 5mm proximal to distal and spanning the entire width of the patellar groove were created and repaired with untreated or TGF-beta1-pretreated periosteal grafts. Post-operatively the rabbits resumed normal cage activity for 6 weeks. Complete filling of the defects with regenerated tissue was observed in both the TGF-beta1-pretreated and control groups with reformation of the original contours of the patellar groove. The total histological score (modified O'Driscoll) in the TGF-beta1-pretreated group, 20 (95% Confidence Interval (CI), 19-21), was significantly higher (P=0.0001) than the control group, 18 (16-19). The most notable improvements were in structural integrity and subchondral bone regeneration. No significant differences in glycosaminoglycan or type...Continue Reading

References

Mar 1, 1991·Journal of Biomedical Materials Research·H P von SchroederR D Coutts
Jul 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H NakaharaA I Caplan
Feb 1, 1990·Acta Orthopaedica Scandinavica·V E HoikkaV A Ritsilä
Dec 1, 1985·Acta Orthopaedica Scandinavica·B NiedermannJ M Rubak
Jan 1, 1972·Scandinavian Journal of Plastic and Reconstructive Surgery·T SkoogS A Sohn
Jan 1, 1995·Archives of Orthopaedic and Trauma Surgery·O L Korkala, H O Kuokkanen
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S H GallayS W O'Driscoll
Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
May 14, 1993·Science·R Langer, J P Vacanti
Sep 1, 1995·Osteoarthritis and Cartilage·S W O'DriscollJ S Fitzsimmons
Nov 25, 1998·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·R LorentzonC Hildingsson
Aug 26, 1999·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·H Alfredson, R Lorentzon
Nov 7, 2000·Clinical Orthopaedics and Related Research·S W O'Driscoll, J S Fitzsimmons
Nov 14, 2000·Journal of Biomedical Materials Research·G N DudaM Sittinger
Apr 4, 2001·The Journal of Bone and Joint Surgery. British Volume·G I ImW H Cho
May 3, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S W O'DriscollJ S Fitzimmons
Jun 12, 2001·Clinics in Sports Medicine·S W O'Driscoll
Oct 18, 2001·Clinical Orthopaedics and Related Research·S W O'Driscoll, J S Fitzsimmons
Jun 1, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hiroshi MizutaShawn W O'Driscoll
Apr 23, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Timothy M SimonDouglas W Jackson
Sep 27, 2003·Tissue Engineering·Dietmar W Hutmacher, Michael Sittinger
Oct 6, 2005·The Journal of Bone and Joint Surgery. American Volume·Rune B JakobsenJames R Slauterbeck
Nov 2, 2005·Tissue Engineering·Rodrigo M MardonesShawn W O'Driscoll
Jul 11, 2008·Journal of Tissue Engineering and Regenerative Medicine·Edwin J P JansenRoel Kuijer
Dec 10, 2008·Osteoarthritis and Cartilage·G G ReinholzS W O'Driscoll

❮ Previous
Next ❯

Citations

May 31, 2013·Journal of the Royal Society, Interface·Katja AhtiainenRiitta Seppänen
Jan 1, 2010·Journal of Long-term Effects of Medical Implants·Peter Petrochenko, Roger J Narayan
Dec 25, 2015·Tissue Engineering. Part a·Chen-Shuang LiYan-Heng Zhou
May 17, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Fatima N Syed-PicardCharles Sfeir
Aug 30, 2011·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Philipp MetzlerKarl Andreas Schlegel
Dec 20, 2011·Osteoarthritis and Cartilage·K SatoY Nishiwaki
Aug 16, 2014·World Journal of Stem Cells·Concetta Ferretti, Monica Mattioli-Belmonte
Feb 20, 2020·Anais Da Academia Brasileira De Ciências·Jaqueline Martins BatistaJosé Angelo Camilli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.