Pretreatment platelet count early predicts extrahepatic metastasis of human hepatoma

Liver International : Official Journal of the International Association for the Study of the Liver
Chern-Horng LeeSen-Yung Hsieh

Abstract

Thrombocytosis is associated with metastasis in many human cancers. Most hepatocellular carcinomas (HCC) develop in cirrhotic livers, which are characterized by thrombocytopenia. We aimed to elucidate the pretreatment platelet count in prediction of extrahepatic metastasis of HCC during the follow-up. Three cohorts containing 1660, 480 and 965 HCC patients enrolled from three hospitals were used for discovery and validation respectively. Pretreatment clinical factors associated with extrahepatic metastasis during follow-up up to 5 years were identified using multivariate Cox regression model. In early-stage HCC (BCLC stage 0-A), pretreatment platelet count (hazard ratio [HR], 1.04 per 10,000/μl; 95% CI, 1.01-1.07; P = 0.010) and serum alpha-foetoprotein (AFP) >100 ng/ml (HR, 1.70; 95% CI, 1.04-2.78; P = 0.033) were the only two independent factors associated with extrahepatic metastasis. Receiver operating characteristic evidenced that pretreatment platelet count predicted metastasis better than AFP did. Survival tree analysis identified platelet counts <118,000/μl (HR, 0.49; 95% CI, 0.38-0.63; P < 0.001) or >212,000/μl (HR, 2.12; 95% CI, 1.67-2.70; P < 0.001) to categorize patients into low and high risk of metastasis subgroup...Continue Reading

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Citations

Mar 24, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Sen-Yung HsiehChen-Chun Lin
Jan 23, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Fatih OzcelikAlpaslan Özgün
May 15, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Sen-Yung HsiehChien-Heng Shen
May 7, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Qing PangChang Liu
Feb 22, 2017·Genes·Rajagopal N Aravalli, Clifford J Steer
Nov 18, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Ton Lisman
Nov 8, 2018·Journal of Gastroenterology and Hepatology·Yu-Qiang ChengShu-Qun Cheng
Jun 9, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Po-Hong LiuTeh-Ia Huo
Oct 13, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sangbin HanJustin Sangwook Ko
Jul 28, 2018·Canadian Journal of Gastroenterology & Hepatology·Bibek AryalYutaka Imoto
Mar 6, 2019·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Chern-Horng LeeSen-Yung Hsieh
Jul 28, 2020·Bioscience Trends·Yutaka MidorikawaMitsuhiko Moriyama
Oct 18, 2019·Cancers·Quirino LaiUNKNOWN Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group
Jul 4, 2020·Journal of Gastrointestinal Cancer·Ramazan DertliHuseyin Ataseven
Apr 11, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Qing PangSushun Liu

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