Abstract
Thrombocytosis is associated with metastasis in many human cancers. Most hepatocellular carcinomas (HCC) develop in cirrhotic livers, which are characterized by thrombocytopenia. We aimed to elucidate the pretreatment platelet count in prediction of extrahepatic metastasis of HCC during the follow-up. Three cohorts containing 1660, 480 and 965 HCC patients enrolled from three hospitals were used for discovery and validation respectively. Pretreatment clinical factors associated with extrahepatic metastasis during follow-up up to 5 years were identified using multivariate Cox regression model. In early-stage HCC (BCLC stage 0-A), pretreatment platelet count (hazard ratio [HR], 1.04 per 10,000/μl; 95% CI, 1.01-1.07; P = 0.010) and serum alpha-foetoprotein (AFP) >100 ng/ml (HR, 1.70; 95% CI, 1.04-2.78; P = 0.033) were the only two independent factors associated with extrahepatic metastasis. Receiver operating characteristic evidenced that pretreatment platelet count predicted metastasis better than AFP did. Survival tree analysis identified platelet counts <118,000/μl (HR, 0.49; 95% CI, 0.38-0.63; P < 0.001) or >212,000/μl (HR, 2.12; 95% CI, 1.67-2.70; P < 0.001) to categorize patients into low and high risk of metastasis subgroup...Continue Reading
References
Jul 24, 1969·The New England Journal of Medicine·M J Goldstein
Sep 24, 1960·JAMA : the Journal of the American Medical Association·E R FISHERB FISHER
Nov 18, 2005·Journal of Hepatology·Hashem B El-SeragKatherine A McGlynn
Aug 14, 2008·Expert Review of Anticancer Therapy·Lubor Borsig
Aug 20, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Miho KandaMasao Omata
Dec 26, 2009·Journal of Hepatology·Chia-Yen DaiWan-Long Chuang
Oct 26, 2010·Lancet·Peter M RothwellTom W Meade
Jan 20, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sen-Yung HsiehShiu-Fen Huang
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Mar 26, 2011·Cancer·Koji UchinoKazuhiko Koike
Apr 9, 2011·Annals of Surgery·Sheung Tat FanSee Ching Chan
Sep 1, 2011·Journal of Proteome Research·Sen-Yung HsiehCheng-Tang Chiu
Nov 19, 2011·Cancer Cell·Myriam LabelleRichard O Hynes
Feb 18, 2012·The New England Journal of Medicine·Rebecca L StoneAnil K Sood
Mar 24, 2012·Lancet·Peter M RothwellZiyah Mehta
May 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sasan RoayaieVincenzo Mazzaferro
Jun 2, 2012·The Oncologist·Li JunShen Feng
Jul 28, 2012·Cancer Research·Lucy A CouplandChristopher R Parish
Sep 12, 2012·Blood·Min Soon ChoVahid Afshar-Kharghan
Nov 14, 2012·Nature Reviews. Gastroenterology & Hepatology·Augusto VillanuevaJosep M Llovet
Jun 22, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maria ReigJordi Bruix
Jul 3, 2013·Cancer Cell·Dagmar SchumacherStefan Offermanns
Jul 13, 2013·Cancer Cell·Ben Z Stanger, Mark L Kahn
Sep 5, 2013·Platelets·Haiyan WangYi Ba
Oct 26, 2013·Liver Cancer·Shi-Ming Lin
Jan 29, 2014·BMC Cancer·Brian I CarrCaterina Messa
Feb 1, 2014·Lancet·Emmanuel A TsochatzisAndrew K Burroughs
Feb 12, 2014·Current Opinion in Critical Care·Constantine J Karvellas, Sean M Bagshaw
Feb 21, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuki MorimotoKazuhide Yamamoto
Citations
Nov 10, 2015·Journal of Hepatology·Qing PangChang Liu
Mar 24, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Sen-Yung HsiehChen-Chun Lin
Jan 23, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Fatih OzcelikAlpaslan Özgün
May 15, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Sen-Yung HsiehChien-Heng Shen
May 7, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Qing PangChang Liu
Feb 22, 2017·Genes·Rajagopal N Aravalli, Clifford J Steer
Nov 18, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Ton Lisman
Nov 8, 2018·Journal of Gastroenterology and Hepatology·Yu-Qiang ChengShu-Qun Cheng
Jun 9, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Po-Hong LiuTeh-Ia Huo
Feb 3, 2018·Oncology Letters·Zhen Kang, Enhua Xiao
Oct 13, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sangbin HanJustin Sangwook Ko
Apr 25, 2018·World Journal of Gastroenterology : WJG·Quirino LaiGianluca Mennini
Jul 28, 2018·Canadian Journal of Gastroenterology & Hepatology·Bibek AryalYutaka Imoto
Mar 6, 2019·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Chern-Horng LeeSen-Yung Hsieh
Jul 28, 2020·Bioscience Trends·Yutaka MidorikawaMitsuhiko Moriyama
Oct 18, 2019·Cancers·Quirino LaiUNKNOWN Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group
Jul 4, 2020·Journal of Gastrointestinal Cancer·Ramazan DertliHuseyin Ataseven
Apr 11, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Qing PangSushun Liu
Nov 8, 2020·BMJ Open·Linbin LuXiong Chen
Dec 29, 2020·Cancer Management and Research·Qing PangHuichun Liu
Oct 30, 2020·Journal of Hepatocellular Carcinoma·Linbin LuXiong Chen
Aug 6, 2021·Anesthesia and Pain Medicine·Sangbin Han
Oct 30, 2021·Journal, Genetic Engineering & Biotechnology·Mohamed M OmranKhaled Farid
Nov 23, 2021·Bioscience Reports·Beibei ZhuHongke Zhou