Pretreatment serum lactate dehydrogenase predicting metastatic spread in Ewing's sarcoma.

Annals of Internal Medicine
H D BreretonT C Pomeroy

Abstract

We measured serum lactate dehydrogenase levels in 36 patients with localized Ewing's sarcoma before treatment. The results were evaluated to determine if the levels served as a prognostic indicator for metastatic spread. After adjusting for primary site of disease and adjuvant chemotherapy, the pretreatment serum lactate dehydrogenase proved an extremely good predictor of which patients would ultimately develop metastatic disease. The median serum lactate dehydrogenase of the total group was between 201 and 214 IU/litre. Three of 18 patients presenting with serum levels of this enzyme of less than or equal to 201 IU/litre ultimately developed metastases, while 16 of 18 patients who presented with serum levels of greater than or equal to 214 IU/litre developed metastases (P less than 0.001).

Citations

Jul 1, 1996·Cancer·R M TerekJ H Healey
Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·N DelépineJ C Desbois
Dec 31, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R D RileyI J Lewis
Mar 10, 2017·Asia-Pacific Journal of Clinical Oncology·Amy Hsin-Chieh HsiehShawgi Sukumaran
Dec 1, 1988·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·T YoshimuraA Suzuki
Jul 1, 1984·Cell Biochemistry and Function·A W Skillen
Jan 1, 1990·Acta Oncologica·T Engan, E Hannisdal
Jan 21, 2017·Molecular and Clinical Oncology·Suoyuan LiYingqi Hua
May 19, 2019·Bone Marrow Transplantation·Zhen-Huan HuMei-Jie Zhang
Jan 1, 1986·International Journal of Radiation Oncology, Biology, Physics·M P BerryW D Rider
Jan 1, 1985·La Ricerca in Clinica E in Laboratorio·G BacciM Campanacci

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