Pretreatment serum levels of hematopoietic cytokines in patients with colorectal adenomas and cancer

International Journal of Colorectal Disease
Barbara MroczkoBogusław Kedra

Abstract

Hematopoietic cytokines (HCs) regulate the proliferation and differentiation of hematopoietic progenitor cells, and it was proved that HCs can promote cancer growth. The aim of this study is to determine whether HCs might be useful in the diagnosis of colorectal cancer. We compared the serum levels of stem cell factor (SCF), interleukin 3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), and macrophage colony-stimulating factor (M-CSF) in 97 colorectal cancer patients with those in 35 patients with colorectal adenomas and 65 healthy subjects (control group). Additionally, we investigated commonly accepted tumor markers, such as carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9). HCs were determined using enzyme linked immunosorbent assay (ELISA). CEA and CA 19-9 were measured by microparticle enzyme immunoassay. Serum levels of GM-CSF, M-CSF, and tumor markers were significantly higher in cancer patients as compared to the control group and adenomas patients. Of these, hematopoietic cytokines were found elevated in the higher proportion of patients than CEA and CA 19-9. The sensitivity of SCF was higher than the sensitivity of other cytokines, but diagnostic specificity and predictive value ...Continue Reading

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Citations

Jul 8, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Marta Łukaszewicz-ZajacMaciej Szmitkowski
Jul 1, 2014·Pancreas·Carolina TorresAna Linares
Jul 20, 2011·Molecular Diagnosis & Therapy·James CreedenDouglas Rex
Jun 3, 2021·Journal of Clinical Medicine·Marta Łukaszewicz-Zając, Barbara Mroczko
Jul 31, 2021·World Journal of Gastroenterology : WJG·Robert S O'Neill, Alina Stoita

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