Pretreatment with alternate day modified fast will permit higher dose and frequency of cancer chemotherapy and better cure rates

Medical Hypotheses
J B JohnsonD R Laub

Abstract

It is established that calorie restriction (CR) increases the resistance of cells to various stressors such as oxidative damage, excitotoxins, mercury and acetaminophen. Alternate day feeding (ADF) may confer greater stress resistance than daily CR of 30% or 40%. A recent study in three strains of mouse showed that a fast of 48 or 60 h prevented toxic effects due to administration of doses 2-4 times the maximum human dose of etoposide, a chemotherapy agent which acts through increased oxidative stress. In addition, mice inoculated with neuroblastoma survived longer when pretreated with fasting, then given high dose etoposide, as well as not exhibiting toxicity. This increased survival was construed as evidence of differential stress resistance between normal and cancer cells, the cancer cells being only partially protected by the pretreatment fast. In clinical practice, increased differential stress resistance could lead to the use of much higher doses of chemotherapy agents, and in the absence of toxicity, make it possible to repeat the treatment to kill residual cancer cells. Humans are unlikely to comply with a total fast of longer than 24 or 48 h, which may be insufficient to activate the same gene expression process. Based...Continue Reading

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Citations

Jun 2, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Aminah Jatoi
Jan 1, 2009·Dose-response : a Publication of International Hormesis Society·Arnold Kahn, Anders Olsen
Feb 25, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Federico Bozzetti, Beth Zupec-Kania
Jul 6, 2018·Analytical and Bioanalytical Chemistry·Monica M Schroll, Amanda B Hummon
Mar 10, 2021·GeroScience·Eleonora DuregonRafael de Cabo

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